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Acetaminophen 500 MG / caffeine 65 MG Oral Tablet — RxCUI 307686

RxNorm drug concept · Semantic clinical drug
RxCUI 307686 Semantic clinical drug · SCD ● Current RxNorm concept 25 FDA products 30 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI307686
Official nameAcetaminophen 500 MG / caffeine 65 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 500 MG / Caffeine 65 MG Oral Tablet
FDA products mapped25
Package NDCs mapped30
Reported Medicaid activity (SDUD)95 prescriptions · 1 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Acetaminophen Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Great question. The IV form is used when you can't take medication by mouth — for example, after surgery, if you're nauseated, or if you need faster, more reliable absorption. It d...
  • Why am I getting acetaminophen through an IV instead of just taking a pill?
  • Yes, Acetaminophen Injection is approved for children — for pain relief in kids 2 years and older, and for fever reduction in patients of all ages, including premature newborns bor...
  • The most important things to watch for are signs of a serious allergic reaction — swelling of your face, mouth, or throat, trouble breathing, or hives — and any new skin rash. Eith...
📖 Read our full Acetaminophen Injection guide →

🕸️ Concept Web — How Acetaminophen 500 MG / caffeine 65 MG Oral Table... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / caffeine 65 MG Oral Tablet RxCUI 307686

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 3

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Caffeine 1886
    • Acetaminophen / caffeine 108038
  2. Brand names 3

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Excedrin Tension Headache 405058
    • Panadol Extra 1872070
    • Sed-Max 1866138
  3. Dose forms 15

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / caffeine Oral Tablet 370515
    • Acetaminophen / caffeine Oral Product 1154884
    • Acetaminophen / caffeine Pill 1154885
    • Acetaminophen / caffeine Oral Tablet [Excedrin Tension Headache] 405991
    • Acetaminophen / caffeine Oral Tablet [Panadol Extra] 1872072
    • Acetaminophen / caffeine Oral Tablet [Sed-Max] 1866140
    • Excedrin Tension Headache Oral Product 1172569
    • Excedrin Tension Headache Pill 1172570
    • +7 more in this family
  4. Clinical & branded drugs 8

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 22 of 29 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 500 MG SCDC · 315266
  • Caffeine 65 MG SCDC · 317311
  • Acetaminophen / caffeine Oral Tablet SCDF · 370515
  • Acetaminophen / caffeine Oral Product SCDG · 1154884
  • Acetaminophen / caffeine Pill SCDG · 1154885

Brand-Name Concepts

📦 FDA Products & Package NDCs

25 products · 30 package NDCs
30 package NDCs map to RxCUI 307686 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-8139-01 1 BOTTLE in 1 CARTON (0067-8139-01) / 24 TABLET, FILM COATE... Excedrin Tension Headache Haleon US Holdings LLC 2016-12-15
00067-8139-02 1 BOTTLE in 1 CARTON (0067-8139-02) / 100 TABLET, FILM COAT... Excedrin Tension Headache Haleon US Holdings LLC 2016-12-15
00067-8147-01 1 KIT in 1 PACKAGE, COMBINATION (0067-8147-01) * 1 BOTTLE... Excedrin PM Triple Action Caplets and Excedrin Tension Headache Haleon US Holdings LLC 2017-06-01
00067-8151-01 1 KIT in 1 PACKAGE, COMBINATION (0067-8151-01) * 1 BOTTLE... Excedrin Extra Strength and Excedrin Tension Headache Haleon US Holdings LLC 2018-09-30
00135-0620-01 1 BOTTLE in 1 CARTON (0135-0620-01) / 24 TABLET, FILM COATE... PANADOL Extra Haleon US Holdings LLC 2017-03-01
00363-7213-10 1 BOTTLE in 1 CARTON (0363-7213-10) / 100 TABLET in 1 BOTTL... TENSION HEADACHE RELIEF WALGREENS 2020-11-17
11673-0839-01 100 TABLET, COATED in 1 CARTON (11673-839-01) TENSION HEADACHE RELIEF TARGET CORPORATION 2020-02-04
11822-0428-02 1 BOTTLE, PLASTIC in 1 CARTON (11822-0428-2) / 100 TABLET,... Tension Headache Aspirin-Free Rite Aid Corporation 2007-01-17
49483-0373-01 100 TABLET in 1 BOTTLE (49483-373-01) Tension Headache Relief TIME CAP LABS INC 2021-06-16
49483-0373-20 200 TABLET in 1 BOTTLE (49483-373-20) Tension Headache Relief TIME CAP LABS INC 2023-08-08
55758-0435-24 1 BOTTLE in 1 CARTON (55758-435-24) / 24 TABLET in 1 BOTTLE DoloDent Toothache For adults Pharmadel LLC 2024-07-30
59779-0824-06 200 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (59779-824-06) Tension Headache Aspirin Free CVS Pharmacy 2007-01-17
59779-0824-21 100 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (59779-824-21) Tension Headache Aspirin Free CVS Pharmacy 2007-01-17
68163-0506-15 1 BOTTLE in 1 CARTON (68163-506-15) / 15 TABLET, FILM COATE... DRX CHOICE Tension Headache Raritan Pharmaceuticals Inc. 2025-05-16
69197-0029-20 1 BOTTLE in 1 CARTON (69197-029-20) / 20 TABLET, COATED in... SED-MAX Command Brands, LLC 2014-11-26
69729-0147-40 1 BOTTLE in 1 CARTON (69729-147-40) / 40 TABLET, FILM COATE... CAFIZETAMOL FORTE OPMX LLC 2023-08-09
69729-0148-40 1 BOTTLE in 1 CARTON (69729-148-40) / 40 TABLET, FILM COATE... Migrafein FORTE OPMX LLC 2023-08-09
69729-0149-24 2 BLISTER PACK in 1 CARTON (69729-149-24) / 12 TABLET, FILM... Neo-Lubrina Fuerte OPMX LLC 2023-08-09
69729-0154-24 2 BLISTER PACK in 1 CARTON (69729-154-24) / 12 TABLET, FILM... Mejoral OPMX LLC 2023-12-05
69729-0793-24 2 BLISTER PACK in 1 CARTON (69729-793-24) / 12 TABLET, FILM... KORTRIBION Pain Reliever OPMX LLC 2025-02-14
69729-0795-24 2 BLISTER PACK in 1 CARTON (69729-795-24) / 12 TABLET, FILM... DOLONEURO-TROPAS OPMX LLC 2025-04-01
69729-0795-80 20 BLISTER PACK in 1 CARTON (69729-795-80) / 4 TABLET, FILM... DOLONEURO-TROPAS OPMX LLC 2026-01-29
69732-0007-01 100 TABLET in 1 BOTTLE, PLASTIC (69732-007-01) Tension Headache Relief Hi-Tech Nutraceuticals, LLC 2020-11-09
70000-0159-01 1 BOTTLE in 1 CARTON (70000-0159-1) / 24 TABLET, FILM COATE... Tension Headache Cardinal Health 110, LLC. DBA Leader 2007-01-17
70000-0159-02 1 BOTTLE in 1 CARTON (70000-0159-2) / 100 TABLET, FILM COAT... Tension Headache Cardinal Health 110, LLC. DBA Leader 2007-01-17
72090-0004-02 200 TABLET in 1 BOTTLE (72090-004-02) Tension Headache Relief Pioneer Life Sciences, LLC 2020-08-03
79903-0373-01 1 BOTTLE in 1 CARTON (79903-373-01) / 100 TABLET in 1 BOTTL... Tension Headache Pain Relieving Aid WAL-MART STORES INC 2024-04-01
82706-0010-01 1 BOTTLE, PLASTIC in 1 CARTON (82706-010-01) / 24 TABLET in... NOTTS - Tension Headache VIVUNT PHARMA LLC 2023-10-30
82706-0010-02 1 BOTTLE, PLASTIC in 1 CARTON (82706-010-02) / 100 TABLET i... NOTTS - Tension Headache VIVUNT PHARMA LLC 2023-10-30
84324-0002-01 100 TABLET in 1 BOTTLE (84324-002-01) Tension Headache Relief NUVICARE LLC 2024-07-30
Observed labelers: OPMX LLC (7) · Haleon US Holdings LLC (5) · Cardinal Health 110, LLC. DBA Leader (2) · CVS Pharmacy (2) · TIME CAP LABS INC (2) · VIVUNT PHARMA LLC (2) · +10 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.