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168 HR estradiol 0.0025 MG/HR Transdermal System [Climara] — RxCUI 404657

RxNorm drug concept · Semantic branded drug
RxCUI 404657 Semantic branded drug · SBD ● Current RxNorm concept 6 FDA products 6 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI404657
Official name168 HR estradiol 0.0025 MG/HR Transdermal System [Climara]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asClimara 0.06 MG/24HR Weekly Transdermal Patch; Climara 0.06 MG/Day Weekly Transdermal System; 168 HR Climara 0.0025 MG/HR Transdermal System
FDA products mapped6
Package NDCs mapped6
Reported Medicaid activity (SDUD)13,584 prescriptions · 8 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

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🕸️ Concept Web — How 168 HR estradiol 0.0025 MG/HR Transdermal System... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept 168 HR estradiol 0.0025 MG/HR Transdermal System [Climara] RxCUI 404657

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Estradiol 4083
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Climara 323984
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Estradiol Transdermal System 1805869
    • Estradiol Topical Product 1165762
    • Estradiol Transdermal Product 1294793
    • Estradiol Transdermal System [Climara] 1805887
    • Climara Topical Product 1172338
    • Climara Transdermal Product 1297126
    • Transdermal System 316987
    • Topical Product 1151122
    • +1 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 13 of 14 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

  • Estradiol 0.0025 MG/HR [Climara] SBDC · 576560
  • Estradiol Transdermal System [Climara] SBDF · 1805887
  • Climara Topical Product SBDG · 1172338
  • Climara Transdermal Product SBDG · 1297126
  • Climara BN · 323984

📦 FDA Products & Package NDCs

6 products · 6 package NDCs
6 package NDCs map to RxCUI 404657 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
50419-0451-04 4 PATCH in 1 CARTON (50419-451-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 1994-12-22
50419-0452-04 4 PATCH in 1 CARTON (50419-452-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 1994-12-22
50419-0453-04 4 PATCH in 1 CARTON (50419-453-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 1998-03-23
50419-0454-04 4 PATCH in 1 CARTON (50419-454-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 1999-03-05
50419-0456-04 4 PATCH in 1 CARTON (50419-456-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 2003-05-27
50419-0459-04 4 PATCH in 1 CARTON (50419-459-04) / 7 d in 1 PATCH (50419-... Climara Bayer HealthCare Pharmaceuticals Inc. 2008-01-03
Observed labelers: Bayer HealthCare Pharmaceuticals Inc. (6) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.