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Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG Oral Tablet — RxCUI 858770

RxNorm drug concept · Semantic clinical drug
RxCUI 858770 Semantic clinical drug · SCD ● Current RxNorm concept 4 FDA products 5 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI858770
Official nameHydrocodone bitartrate 2.5 MG / ibuprofen 200 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
FDA products mapped4
Package NDCs mapped5
Reported Medicaid activity (SDUD)1,364 prescriptions · 20 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Hydrocodone: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • This extended-release form of hydrocodone is designed for pain that is severe and present all day, every day — the kind that needs steady, around-the-clock control rather than occa...
  • Why did my doctor prescribe this instead of a regular pain pill?
  • Absolutely not — and this is one of the most important things to know. These products are engineered to release hydrocodone slowly over many hours. If you crush, chew, break, or di...
  • Can I crush or cut the tablet or capsule to make it easier to swallow?
📖 Read our full Hydrocodone guide →

🕸️ Concept Web — How Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG Oral Tablet RxCUI 858770

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Hydrocodone 5489
    • Ibuprofen 5640
    • Hydrocodone / ibuprofen 214627
    • Hydrocodone bitartrate 142439
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Reprexain 579458
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Hydrocodone / ibuprofen Oral Tablet 370676
    • Hydrocodone bitartrate / ibuprofen Oral Tablet 2647346
    • Hydrocodone / ibuprofen Oral Product 1162788
    • Hydrocodone / ibuprofen Pill 1162789
    • Hydrocodone bitartrate / ibuprofen Oral Product 2661559
    • Hydrocodone bitartrate / ibuprofen Pill 2663575
    • Hydrocodone / ibuprofen Oral Tablet [Reprexain] 724134
    • Hydrocodone bitartrate / ibuprofen Oral Tablet [Reprexain] 2658286
    • +5 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Hydrocodone bitartrate 2.5 MG 857110
    • Ibuprofen 200 MG 316074
    • Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG Oral Tablet [Reprexain] 858772
    • Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG [Reprexain] 858771

Showing up to 8 concepts per family — 17 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Hydrocodone bitartrate 2.5 MG SCDC · 857110
  • Ibuprofen 200 MG SCDC · 316074
  • Hydrocodone / ibuprofen Oral Tablet SCDF · 370676
  • Hydrocodone bitartrate / ibuprofen Oral Tablet SCDFP · 2647346
  • Hydrocodone / ibuprofen Oral Product SCDG · 1162788
  • Hydrocodone / ibuprofen Pill SCDG · 1162789
  • Hydrocodone bitartrate / ibuprofen Oral Product SCDGP · 2661559
  • Hydrocodone bitartrate / ibuprofen Pill SCDGP · 2663575

Brand-Name Concepts

  • Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG Oral Tablet [Reprexain] SBD · 858772
  • Hydrocodone bitartrate 2.5 MG / ibuprofen 200 MG [Reprexain] SBDC · 858771
  • Hydrocodone / ibuprofen Oral Tablet [Reprexain] SBDF · 724134
  • Hydrocodone bitartrate / ibuprofen Oral Tablet [Reprexain] SBDFP · 2658286
  • Reprexain Oral Product SBDG · 1181342
  • Reprexain Pill SBDG · 1181345
  • Reprexain BN · 579458

📦 FDA Products & Package NDCs

4 products · 5 package NDCs
5 package NDCs map to RxCUI 858770 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
53746-0116-01 100 TABLET in 1 BOTTLE (53746-116-01) Hydrocodone Bitartrate and Ibuprofen Amneal Pharmaceuticals of New York LLC 2010-02-18
53746-0117-01 100 TABLET in 1 BOTTLE (53746-117-01) Hydrocodone Bitartrate and Ibuprofen Amneal Pharmaceuticals of New York LLC 2010-02-18
53746-0145-01 100 TABLET in 1 BOTTLE (53746-145-01) Hydrocodone Bitartrate and Ibuprofen Amneal Pharmaceuticals of New York LLC 2010-02-18
53746-0145-05 500 TABLET in 1 BOTTLE (53746-145-05) Hydrocodone Bitartrate and Ibuprofen Amneal Pharmaceuticals of New York LLC 2010-02-18
53746-0146-01 100 TABLET in 1 BOTTLE (53746-146-01) Hydrocodone Bitartrate and Ibuprofen Amneal Pharmaceuticals of New York LLC 2010-02-18
Observed labelers: Amneal Pharmaceuticals of New York LLC (5) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.