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Codeine phosphate 2 MG/ML / promethazine hydrochloride 1.25 MG/ML Oral Solution — RxCUI 991486

Name: Codeine phosphate 2 MG/ML / promethazine hydrochloride 1.25 MG/ML Oral Solution (RxCUI 991486)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 991486 Semantic clinical drug · SCD ● Current RxNorm concept 5 FDA products 7 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI991486

Official nameCodeine phosphate 2 MG/ML / promethazine hydrochloride 1.25 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known ascodeine phosphate 10 MG / promethazine HCl 6.25 MG per 5 ML Oral Syrup; codeine phosphate 10 MG / promethazine HCl 6.25 MG in 5 mL Oral Solution

FDA products mapped5

Package NDCs mapped7

Reported Medicaid activity (SDUD)21,535 prescriptions · 33 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Codeine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Codeine Sulfate tablets are used to treat mild to moderate pain when other pain relievers — like ibuprofen or acetaminophen — haven't worked well enough. It's an opioid, so it's on...
This is really important: do not drink alcohol while taking codeine — the combination can dangerously slow or stop your breathing. The same goes for sleep aids, anxiety medications...
Can I take codeine with my other medications or have a drink?
The most common things people notice are drowsiness, dizziness, nausea, constipation, and sweating — those are expected and usually manageable. What you need to watch out for are s...

📖 Read our full Codeine guide →

🕸️ Concept Web — How Codeine phosphate 2 MG/ML / promethazine hydroch... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Codeine phosphate 2 MG/ML / promethazine hydrochloride 1.25 MG/ML Oral Solution RxCUI 991486 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 5

The active substance itself — no strength, form, or brand attached yet.
- Codeine 2670 IN
- Promethazine 8745 IN
- Codeine / promethazine 214444 MIN
- Codeine phosphate 2672 PIN
- Promethazine hydrochloride 142445 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Codeine / promethazine Oral Solution 375719 SCDF
- Codeine phosphate / promethazine hydrochloride Oral Solution 2647291 SCDFP
- Codeine / promethazine Oral Liquid Product 1155151 SCDG
- Codeine / promethazine Oral Product 1155152 SCDG
- Codeine phosphate / promethazine hydrochloride Oral Liquid Product 2660055 SCDGP
- Codeine phosphate / promethazine hydrochloride Oral Product 2661038 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 2

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Codeine phosphate 2 MG/ML 832866 SCDC
- Promethazine hydrochloride 1.25 MG/ML 991457 SCDC

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Codeine phosphate 2 MG/ML SCDC · 832866
Promethazine hydrochloride 1.25 MG/ML SCDC · 991457
Codeine / promethazine Oral Solution SCDF · 375719
Codeine phosphate / promethazine hydrochloride Oral Solution SCDFP · 2647291
Codeine / promethazine Oral Liquid Product SCDG · 1155151
Codeine / promethazine Oral Product SCDG · 1155152
Codeine phosphate / promethazine hydrochloride Oral Liquid Product SCDGP · 2660055
Codeine phosphate / promethazine hydrochloride Oral Product SCDGP · 2661038

📦 FDA Products & Package NDCs

5 products · 7 package NDCs

7 package NDCs map to RxCUI 991486 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00713-0823-75	473 mL in 1 BOTTLE, PLASTIC (0713-0823-75)	Promethazine Hydrochloride and Codeine Phosphate	Cosette Pharmaceuticals, Inc.	2025-12-19
17856-0065-01	72 CUP, UNIT-DOSE in 1 BOX, UNIT-DOSE (17856-0065-1) / 5 mL...	Promethazine Hydrochloride and Codeine Phosphate	ATLANTIC BIOLOGICALS CORP.	2020-08-07
17856-0065-02	1 CUP, UNIT-DOSE in 1 BAG (17856-0065-2) / 5 mL in 1 CUP, U...	Promethazine Hydrochloride and Codeine Phosphate	ATLANTIC BIOLOGICALS CORP.	2025-06-04
27808-0065-02	473 mL in 1 BOTTLE, PLASTIC (27808-065-02)	Promethazine Hydrochloride and Codeine Phosphate	Cranbury Pharmaceuticals, LLC	2018-03-12
70752-0139-06	118 mL in 1 BOTTLE, PLASTIC (70752-139-06)	Promethazine Hydrochloride and Codeine Phosphate	QUAGEN PHARMACEUTICALS LLC	2020-10-08
70752-0139-12	473 mL in 1 BOTTLE, PLASTIC (70752-139-12)	Promethazine Hydrochloride and Codeine Phosphate	QUAGEN PHARMACEUTICALS LLC	2020-10-08
72162-2042-02	473 mL in 1 BOTTLE, PLASTIC (72162-2042-2)	Promethazine Hydrochloride and Codeine Phosphate	Bryant Ranch Prepack	2018-03-12

Observed labelers: ATLANTIC BIOLOGICALS CORP. (2) · QUAGEN PHARMACEUTICALS LLC (2) · Bryant Ranch Prepack (1) · Cosette Pharmaceuticals, Inc. (1) · Cranbury Pharmaceuticals, LLC (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

💲 Pricing (NADAC)

NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.

Per ml · median

$0.0643

Range $0.0643–$0.0643 · middle 50% $0.0643–$0.0643 · 3 NDCs

Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.