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1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] — RxCUI 993456

Name: 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] (RxCUI 993456)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic branded drug

RxCUI 993456 Semantic branded drug · SBD ● Current RxNorm concept 1 FDA product 2 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI993456

Official name1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia]

Concept typeSemantic branded drug (SBD)

RxNorm statusCurrent RxNorm concept

Also known as1 ML Prolia 60 MG/ML Prefilled Syringe; Prolia 60 MG in 1 ML Prefilled Syringe; Prolia 60 MG per 1 ML Prefilled Syringe

FDA products mapped1

Package NDCs mapped2

Reported Medicaid activity (SDUD)48,252 prescriptions · 52 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Denosumab Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

Denosumab works by blocking a protein in your body that signals bone-dissolving cells to break down bone. By slowing that process, it helps your bones stay denser and stronger — wh...
What exactly does this injection do, and why do I need it?
You only need the injection once every 6 months — so just two visits a year. Between those visits, the most important thing you can do is take your calcium and vitamin D every sing...
How often do I have to come in for the shot, and what do I need to do between visits?

📖 Read our full Denosumab Injection guide →

🕸️ Concept Web — How 1 ML denosumab 60 MG/ML Prefilled Syringe [Proli... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept 1 ML denosumab 60 MG/ML Prefilled Syringe [Prolia] RxCUI 993456 Semantic branded drug · SBD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 1

The active substance itself — no strength, form, or brand attached yet.
- Denosumab 993449 IN
Brand names 1

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Prolia 993453 BN
Dose forms 6

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Denosumab Prefilled Syringe 993451 SCDF
- Denosumab Injectable Product 1157742 SCDG
- Denosumab Prefilled Syringe [Prolia] 993455 SBDF
- Prolia Injectable Product 1181276 SBDG
- Prefilled Syringe 721656 DF
- Injectable Product 1151126 DFG
Clinical & branded drugs 3

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- 1 ML denosumab 60 MG/ML Prefilled Syringe 993452 SCD
- Denosumab 60 MG/ML 993450 SCDC
- Denosumab 60 MG/ML [Prolia] 993454 SBDC

Showing up to 8 concepts per family — 11 of 11 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

1 ML denosumab 60 MG/ML Prefilled Syringe SCD · 993452
Denosumab 60 MG/ML SCDC · 993450
Denosumab Prefilled Syringe SCDF · 993451
Denosumab Injectable Product SCDG · 1157742

Brand-Name Concepts

Denosumab 60 MG/ML [Prolia] SBDC · 993454
Denosumab Prefilled Syringe [Prolia] SBDF · 993455
Prolia Injectable Product SBDG · 1181276
Prolia BN · 993453

📦 FDA Products & Package NDCs

1 product · 2 package NDCs

2 package NDCs map to RxCUI 993456 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
55513-0710-01	1 SYRINGE in 1 CARTON (55513-710-01) / 1 mL in 1 SYRINGE	Prolia	Amgen, Inc	2010-06-05
55513-0710-21	1 SYRINGE in 1 CARTON (55513-710-21) / 1 mL in 1 SYRINGE	Prolia	Amgen, Inc	2024-03-05

Observed labelers: Amgen, Inc (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

💲 Pricing (NADAC)

NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.

Per ml · median

$1,864.6300

Range $1,864.6300–$1,864.6300 · middle 50% $1,864.6300–$1,864.6300 · 2 NDCs

Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.

🧾 Billing Codes (HCPCS)

Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.

Code	Descriptor	Mapped packages	Sources
J0897	Denosumab injection	2	CMS

⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.