Advair HFA (Fluticasone Propionate and Salmeterol Xinafoate) Inhaler shortage
Not a nationwide shortage — GlaxoSmithKline has told the FDA it is discontinuing its fluticasone propionate and salmeterol xinafoate inhalers. The FDA lists this under “To be discontinued” as of Oct 7, 2026: a company stopping its own product. 2 other companies sell the same medicine and have not reported a problem, so your pharmacy may be able to order another company’s version.
GlaxoSmithKline is stopping its Advair HFA (fluticasone/salmeterol) inhaler, with distribution ending around December 31, 2026. Other manufacturers still list Advair HFA and fluticasone/salmeterol HFA inhalers as available.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this medicine? See the ‘What to do’ note from Dr. Brian Staiger, PharmD →Is Advair HFA still in shortage? — status as of Oct 7, 2026
Still listed as “To be discontinued” as of Oct 7, 2026. GlaxoSmithKline is stopping its own version only; 2 other companies still sell the same medicine and have not reported a problem. Your pharmacy may need to order another company’s version.
The charts count only the companies that reported this shortage to the FDA; companies that haven’t reported a problem are in the green card, and the Supply-Risk rating counts them too.
Shortage timeline
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Jul 27, 2026Currently in shortage3 of 3 products affected.
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Jul 27, 2026First reported to the FDA3 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
Which Advair HFA products are affected — by company
Company: GlaxoSmithKline 📞 888-825-5249 3 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Advair HFA Inhaler, 45 ug; 21 ug | 45 ug; 21 ug | — | The anticipated date that GSK will cease distribution of the presentation is approximately December 31, 2026. The 120 dose presentation of this product will still be available. | — |
| To Be Discontinued | Advair HFA Inhaler, 115 ug; 21 ug | 115 ug; 21 ug | — | The anticipated date that GSK will cease distribution of the presentation is approximately December 31, 2026. The 120 dose presentation of this product will still be available. | — |
| To Be Discontinued | Advair HFA Inhaler, 230 ug; 21 ug | 230 ug; 21 ug | — | The anticipated date that GSK will cease distribution of the presentation is approximately December 31, 2026. The 120 dose presentation of this product will still be available. | — |
These rows are company reports to the FDA for Fluticasone Propionate and Salmeterol Xinafoate Inhaler — they do not cover every company that lists this medicine. A company appears here only if it told the FDA it has a supply problem, so other companies may still have stock. That’s the basis for the Where else can I get Advair HFA or its generic? options further down this page.
Why is GlaxoSmithKline discontinuing Advair HFA?
GlaxoSmithKline has reported that it is permanently stopping distribution of certain package sizes of Advair HFA. Specifically, all three strengths — 45 mcg/21 mcg, 115 mcg/21 mcg, and 230 mcg/21 mcg — in what appears to be a smaller canister size (the specific NDCs listed) are expected to be phased out, with GSK anticipating it will stop shipping these presentations around December 31, 2026. No specific reason was shared publicly for why this packaging is being discontinued.
The good news is that GSK has noted that the 120-dose canister versions of all three strengths will still be available. So it's the specific package presentation being stopped — not the medication or its strengths altogether, at least from this manufacturer.
Based on the company-reported reason(s) and notes on file with the FDA for Fluticasone Propionate and Salmeterol Xinafoate Inhaler, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as companies report changes.
What should I do if I take Advair HFA?
Advair HFA (fluticasone propionate and salmeterol inhalation aerosol) is currently on the FDA shortage list. This affects the inhaler you may use for asthma, so let me walk you through what the report shows.
The notice comes from GlaxoSmithKline (GSK) and covers all three strengths they make: 45/21 mcg, 115/21 mcg, and 230/21 mcg. GSK has marked these as to be discontinued, with distribution expected to end around December 31, 2026. One important detail in their note: the 120-dose presentation of this product will still be available. This means the supply change may be permanent for the affected presentation, so a conversation with your prescriber is the right next step.
Here is what I suggest, in order:
- Do not stop, skip, or change how you use your inhaler on your own.
- Ask your pharmacy to check wholesalers and other makers — the same medicine is listed from other suppliers, such as Prasco Laboratories and A-S Medication Solutions. Your pharmacy may be able to source one of these, though it may not be in local stock.
- If your exact inhaler cannot be found, ask your prescriber or pharmacist about a suitable option chosen for you.
GSK's contact number is listed on this page for reference; pharmacies usually handle those calls. This is national data and may not match your local pharmacy's actual stock.
- Ask your pharmacy to check other companies’ versions, other strengths, package sizes, and nearby stores — the options below are a starting point.
- If this is part of an ongoing or essential regimen (for example HIV, seizure, heart, transplant, diabetes or mental-health medicines), arrange continued supply before you run out rather than rationing doses.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Advair HFA or its generic?
FDA shortages are company-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every company that lists fluticasone propionate and salmeterol xinafoate inhalers is necessarily short. Below are the other listings in the current FDA NDC Directory that are not reported in shortage: the same medicine from companies that haven’t reported a problem (the reporting company is excluded), and other dosage forms. These are generic versions of Advair HFA — a switch from the brand goes through your pharmacist or prescriber. Some listings are repackagers, which relabel another company’s product. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine from other companies (not reporting a shortage)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from companies that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Company | NDC |
|---|---|---|---|---|
| Advair Hfa | FLUTICASONE PROPIONATE 115 ug/1; SALMETEROL XINAFOATE 21 ug/1 | Aerosol, Metered · Respiratory (Inhalation) | A-S Medication Solutions | 50090-3672-00 |
| Fluticasone Propionate And Salmeterol Hfa | FLUTICASONE PROPIONATE 45 ug/1; SALMETEROL XINAFOATE 21 ug/1 | Aerosol, Metered · Respiratory (Inhalation) | Prasco Laboratories | 66993-0086-96 |
| Fluticasone Propionate And Salmeterol Hfa | FLUTICASONE PROPIONATE 115 ug/1; SALMETEROL XINAFOATE 21 ug/1 | Aerosol, Metered · Respiratory (Inhalation) | Prasco Laboratories | 66993-0087-96 |
| Fluticasone Propionate And Salmeterol Hfa | FLUTICASONE PROPIONATE 230 ug/1; SALMETEROL XINAFOATE 21 ug/1 | Aerosol, Metered · Respiratory (Inhalation) | Prasco Laboratories | 66993-0088-96 |
Other dosage forms of fluticasone propionate and salmeterol xinafoate
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 8 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Fluticasone Propionate and Salmeterol HFA 45 ug/1; 21 ug | Prasco | 1 inhaler | $16.678 | — | Availability likely |
| Advair Hfa 115 ug/1; 21 ug | GlaxoSmithKline | 1 inhaler | $18.731 | — | Availability likely |
| Advair Hfa 45 ug/1; 21 ug | GlaxoSmithKline | 1 inhaler | $20.018 | — | Availability likely |
| Fluticasone Propionate and Salmeterol HFA 115 ug/1; 21 ug | Prasco | 1 inhaler | $20.708 | — | Availability likely |
| Fluticasone Propionate and Salmeterol HFA 230 ug/1; 21 ug | Prasco | 1 inhaler | $26.746 | — | Availability likely |
| Advair Hfa 230 ug/1; 21 ug | GlaxoSmithKline | 1 inhaler | $30.531 | — | Availability likely |
| Advair Hfa 115 ug/1; 21 ug | A-S | 1 inhaler | — | — | FDA listed |
| Advair Hfa 115 ug/1; 21 ug | A-S | 1 inhaler | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Advair HFA — that fall in the same broad treatment class (beta-adrenergic and glucocorticoid combo, inhaled) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Codes & classification for pharmacists and billers
Where does this data come from?
Other pulmonary/allergy shortages
Advair HFA shortage FAQs
Is Advair HFA still in shortage?
Which strengths of Advair HFA are affected?
Which Advair HFA products are affected?
When will Advair HFA be available again?
Can I still get Advair HFA or its generic somewhere?
Is the brand or the generic affected?
What should I do if I take Advair HFA?
Still have a question about the Advair HFA shortage?
Ask a pharmacist about this shortage →View Fluticasone Propionate And Salmeterol Xi... on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (companies listing the same ingredient & form — the "other companies" the rating counts); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.