Podocon 25, Topical Tincture (Podophyllum Resin Topical Tincture) shortage
Not a nationwide shortage — Padagis US has told the FDA it is discontinuing its podophyllum resin topical tincture. The FDA lists this under “To be discontinued” as of Oct 5, 2026: a company stopping its own product. 1 other company sells the same medicine and has not reported a problem, so your pharmacy may be able to order another company’s version.
Padagis is stopping production of Podophyllum Resin Topical Tincture, and this change may be permanent. Podocon-25 (podophyllum resin) 1 mg/4 mL tincture is still listed as available from Bryant Ranch Prepack.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this medicine? See the ‘What to do’ note from Dr. Brian Staiger, PharmD →Is Podocon 25, Topical Tincture still in shortage? — status as of Oct 5, 2026
Still listed as “To be discontinued” as of Oct 5, 2026. Padagis US is stopping its own version only; 1 other company still sells the same medicine and has not reported a problem. Your pharmacy may need to order another company’s version.
The charts count only the companies that reported this shortage to the FDA; companies that haven’t reported a problem are in the green card, and the Supply-Risk rating counts them too.
Shortage timeline
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Jul 23, 2026Currently in shortage1 of 1 product affected.
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Jul 23, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
Which Podocon 25, Topical Tincture products are affected — by company
Company: Padagis US LLC 📞 (800) 775-2054 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Podocon 25, Topical Tincture, 1 mg/4 mL | 1 mg/4 mL | — | Discontinuation of the manufacture of the drug | — |
These rows are company reports to the FDA for Podophyllum Resin Topical Tincture — they do not cover every company that lists this medicine. A company appears here only if it told the FDA it has a supply problem, so other companies may still have stock. That’s the basis for the Where else can I get Podocon 25, Topical Tincture or its generic? options further down this page.
Why is Padagis US discontinuing Podocon 25, Topical Tincture?
Padagis US LLC has reported to the FDA that they are permanently stopping production of their Podocon-25 topical tincture — specifically the 1 mg/4 mL package size. This isn't a temporary shortage or a factory delay; it's a full discontinuation of manufacturing for this particular product from this company.
Padagis did not share a specific public reason explaining why they made this decision — just that manufacturing will be discontinued. It's also worth knowing that this report only reflects what Padagis has filed with the FDA, so it speaks only to their product and not to what other manufacturers may or may not be doing with similar products.
Based on the company-reported reason(s) and notes on file with the FDA for Podophyllum Resin Topical Tincture, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as companies report changes.
What should I do if I take Podocon 25, Topical Tincture?
Podophyllum Resin Topical Tincture is currently listed on the FDA drug-shortage report. I want to walk you through what this means so you know what to expect.
There is only one strength involved here: the 1 mg/4 mL topical tincture (Podocon 25). That strength does not have an available source right now. The reason reported is that the manufacturer, Padagis US LLC, is discontinuing production of this product. Because the record shows it is being discontinued, this supply problem may be a lasting one rather than a short-term gap — which makes a conversation with your prescriber the right next step.
Here is what I suggest:
- Do not stop or change how you use this medicine on your own. Keep following your current directions.
- Ask your pharmacy to check with wholesalers and other suppliers. Our records show the same medicine and strength (Podocon 25, podophyllum resin 1 mg/4 mL) listed from another maker, Bryant Ranch Prepack — your pharmacy may be able to source it, though it may not be sitting in local stock.
- Since this product is being discontinued, ask your prescriber or pharmacist about a clinician-chosen alternative for your situation.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually make these calls. This is national, manufacturer-reported information and may not match your local pharmacy's actual stock.
- Ask your pharmacy to check other companies’ versions, other strengths, package sizes, and nearby stores — the options below are a starting point.
- If this is part of an ongoing or essential regimen (for example HIV, seizure, heart, transplant, diabetes or mental-health medicines), arrange continued supply before you run out rather than rationing doses.
Where else can I get Podocon 25, Topical Tincture or its generic?
FDA shortages are company-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every company that lists podophyllum resin topical tincture is necessarily short. Below are the other listings in the current FDA NDC Directory that are not reported in shortage: the same medicine from companies that haven’t reported a problem (the reporting company is excluded), and other dosage forms. These are generic versions of Podocon 25, Topical Tincture — a switch from the brand goes through your pharmacist or prescriber. Some listings are repackagers, which relabel another company’s product. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine from other companies (not reporting a shortage)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from companies that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Company | NDC |
|---|---|---|---|---|
| Podocon 25 | PODOPHYLLUM RESIN 1 mg/4mL | Tincture · Topical | Bryant Ranch Prepack | 63629-8699-01 |
Therapeutic equivalents & pricing 4 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Podocon 25 1 mg/4mL | Bryant | 1 bottle | — | — | FDA listed |
| Podocon 25 1 mg/4mL | Bryant | 1 bottle | — | — | FDA listed |
| Podocon 25 1 mg/4mL | Padagis | 1 bottle | — | — | FDA listed |
| Podocon 25 1 mg/4mL | Bryant | 1 bottle | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Podocon 25, Topical Tincture — that fall in the same broad treatment class (keratolytics) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Codes & classification for pharmacists and billers
Where does this data come from?
Other dermatology shortages
Podocon 25, Topical Tincture shortage FAQs
Is Podocon 25, Topical Tincture still in shortage?
Which strengths of Podocon 25, Topical Tincture are affected?
Which Podocon 25, Topical Tincture products are affected?
When will Podocon 25, Topical Tincture be available again?
Can I still get Podocon 25, Topical Tincture or its generic somewhere?
Is the brand or the generic affected?
What should I do if I take Podocon 25, Topical Tincture?
Still have a question about the Podocon 25, Topical Tincture shortage?
Ask a pharmacist about this shortage →View Podophyllum Resin Topical Tincture on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (companies listing the same ingredient & form — the "other companies" the rating counts); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.