Drug-induced nutrient depletion

Lumiracoxib & Nutrient Depletion

Also searched as Prexige. What the clinical evidence reports, what it may mean, and what to discuss with your pharmacist.

Medical content reviewed by Dr. Brian Staiger, PharmD, BCPS · Last reviewed July 2026
1Nutrient association
Insufficient EvidenceHighest rating
The bottom line

Lumiracoxib has been associated with depletion of FOLIC ACID. This does not mean a deficiency will occur — it means these are worth knowing about and, if you take Lumiracoxib long-term, worth raising with your pharmacist or healthcare provider.

Ask a pharmacist about Lumiracoxib Free · usually answered within 24 hours

Take more than one medication? Open the checker with Lumiracoxib pre-loaded and add the rest to see overlapping nutrient signals.

The evidence

Reported nutrient depletions with Lumiracoxib

Each record below is shown as published in our licensed clinical database, with its evidence rating and citations. Expand a section for food sources and talking points.

FOLIC ACID

Insufficient Evidence

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

It is unclear if NSAIDs can reduce serum folate levels.

Folate-dependent enzymes are inhibited in vitro by NSAIDs with carboxylic acid-containing side chains. The clinical significance of this inhibition is unknown. For information on foods that are rich in folate, see our chart.
Taking Lumiracoxib? Insufficient evidence to rate; clinical significance is not known. ⓘ
Dr. Brian Staiger, Pharm.D explains

Folic acid is a B vitamin your body uses to build DNA and keep cells dividing properly, including red blood cells. Lumiracoxib belongs to a class of anti-inflammatory drugs that contain a carboxylic acid group in their chemical structure, and some lab studies suggest that structure may interfere with enzymes that process folate in the body. That said, whether this actually lowers folate levels in real patients is simply not known yet, so the evidence is rated as insufficient. If you have been taking lumiracoxib long term and are curious about your folate status, it is worth bringing up with your doctor or pharmacist.

What Folic acid (folate) does & food sources

Folate is needed for cell division, red blood cell formation, and healthy fetal development.

Common food sources:

  • Leafy green vegetables
  • Beans, lentils, and peas
  • Fortified grains and cereals
  • Citrus fruits

HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.

What to discuss with your clinician

Ask your provider whether folate monitoring or supplementation is appropriate for you — this matters most before and during pregnancy, and with long-term use of certain seizure or arthritis medications.

HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.

Supplement considerations

Folate needs are individual. With some medications (for example, methotrexate), folic acid is often prescribed deliberately on a specific schedule — follow your prescriber's instructions rather than adding your own.

Do not start or stop medications or supplements without professional guidance — supplements can interact with prescription medications.

HelloPharmacist pharmacist-reviewed education — separate from the licensed record above.

Caution: High-dose folic acid can mask vitamin B12 deficiency, so the two are often evaluated together.

Learn more about this nutrient: Folic Acid — uses, safety & interactions

References (2)
  1. Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999.
  2. Baggott JE, Morgan SL, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J 1992;282:197-202. PubMed
Important

This tool is educational and is not a substitute for professional medical advice. An association is not a diagnosis and does not mean a deficiency will occur. Always talk to your pharmacist or healthcare provider before starting, stopping, or changing any medication or supplement.

Disclaimer: This checker finds which nutrients might be depleted by prescription or over-the-counter medications. Each nutrient depletion issue is rated based on clinical significance. Use your own professional judgment prior to making clinical decisions.

© 2026 Therapeutic Research Center Licensed records refresh weekly · last updated July 3, 2026.
Keep exploring

More about Lumiracoxib

Understand the basics

What drug-induced nutrient depletion means

Some medications can, over time, lower the levels of certain vitamins, minerals, or other nutrients — through reduced absorption, increased loss, or changes in how the body uses them.

Association is not deficiency

An entry here means a depletion has been reported or studied — not that it happens to everyone, or that you are deficient. Dose, duration, diet, and your own health all matter.

Evidence varies by pair

Some drug–nutrient links (like metformin and vitamin B12) are well studied; others rest on limited or preliminary research. Each entry shows the evidence rating from our licensed clinical database.

When to ask about labs

If you take an associated medication long-term, ask your healthcare provider whether monitoring is appropriate for you. Not everyone needs testing — your provider can weigh your dose, duration, and symptoms.

Don't self-supplement blindly

Supplements are not risk-free: some can interact with medications, and some (like potassium or magnesium) can be risky with kidney disease. Talk to your pharmacist before adding anything.

Never stop a medication over this

These medications are prescribed for good reasons, and the benefit usually far outweighs a manageable nutrient consideration. Any change belongs in a conversation with your prescriber.

Food first, usually

For many nutrients, a varied diet covers the gap. Each entry lists common food sources; a supplement is a decision to make with your pharmacist or provider, not a default.

Common questions

Lumiracoxib & nutrients: FAQs

Does Lumiracoxib deplete FOLIC ACID?
Lumiracoxib has been associated with lower FOLIC ACID levels in the clinical literature — see the evidence rating and details above. An association is not a guarantee: dose, duration, diet, and your own health all matter. If you take Lumiracoxib long-term, ask your healthcare provider whether checking your FOLIC ACID status is appropriate.
Should I take a supplement because I take Lumiracoxib?
Not automatically. The right first step is usually a conversation with your pharmacist or provider — they can weigh your dose and duration, decide whether testing makes sense, and recommend food-first strategies or a supplement if genuinely needed. Some supplements can interact with medications, so do not add one without checking.
Should I stop taking Lumiracoxib?
No — never stop a prescribed medication because of a nutrient association. Lumiracoxib is prescribed for good reasons, and nutrient considerations are usually manageable with monitoring or diet. Any change to your medication belongs in a conversation with your prescriber.
Where does this information come from?
The depletion records come from the Natural Medicines (Therapeutic Research Center) database — an evidence-graded clinical reference — and are displayed as published, with their citations. The plain-English context is written and reviewed by licensed HelloPharmacist pharmacists.

Questions about Lumiracoxib and your nutrition?

Ask a licensed pharmacist — free, no appointment needed.

Ask a pharmacist
Sources

Sources & How We Checked

Nutrient depletion records for Lumiracoxib are evidence-graded and sourced from the Natural Medicines database, and are displayed as published with their citations.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.