Amoxicillin With Propranolol Interaction Details

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between amoxicillin and propranolol.

1 min read Updated Jun 2026 Read by 6,925 people
Amoxicillin With Propranolol Interaction Details
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Sharon asked

Can I take 500 mg amoxicillin and propranolol together? l I've been prescribed amoxicillin for an infection whilst on holiday, but I use propranolol to fly.

Nov 02, 2022
The quick answer
  • Amoxicillin and propranolol have no known drug interaction and are safe to take together.
  • While both drugs are excreted through the kidneys, no actual interaction has been documented between them in practice.
  • You can continue taking both medications as prescribed without concern.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

There is no known drug interaction between propranolol and amoxicillin. They are considered safe together.

I do want to point out that some drug resources (e.g., DrugBank) may list a minor interaction between the two drugs since both are excreted via the kidneys. Theoretically, when two or more medications that are primarily excreted by the kidney are taken together, it could reduce the elimination rate of one, or both, of the drugs.

This doesn't appear to be the case between amoxicillin and propranolol however, and no interaction has been documented between them.

So, yes, it is safe to continue taking your amoxicillin, and propranolol as needed.

Drug Information

If you are looking for more information on either drug in this question, you can visit our drug detail pages:

Final Words

Thanks so much for reaching out!

References & sources
  1. Amoxicillin Monograph — PubChem
  2. Propranolol Monograph — PubChem
  3. DrugBank Interactions — DrugBank
Glossary — Terms in This Answer
Drug interaction
A change in how one medication works when taken together with another medication.
Propranolol
A medication that belongs to a class of drugs called beta-blockers, commonly used to treat high blood pressure and heart conditions.
Amoxicillin
An antibiotic medication used to treat bacterial infections.
Excreted
Removed from the body through urine, sweat, or other bodily processes.
Kidneys
Organs in your body that filter waste products and water from your blood to form urine.
Elimination rate
The speed at which your body removes a drug from your system.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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