Can You Cut Lisinopril Tablets In Half?

In our latest question and answer, the pharmacist discusses whether or not lisinopril tablets can safely be cut in half.


Hi, I am taking lisinopril 40mg and my blood pressure is good. My doctor is switching me to 20mg but I have plenty of 40mg on hand. Can I just split these lisinopril 40mg tablets in half?

Asked by Stephanie On Nov 10, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 11, 2022
Last updated Jul 18, 2024

Key points

  • Lisinopril tablets can safely be cut in half. They can also be crushed and sprinkled onto food.


Yes, lisinopril tablets can safely be cut in half. In fact, many lisinopril tablets have a score mark down the middle to make cutting them easier. However, even if they don't have a score mark, they can still be split. Just make sure to use a sharp knife or dedicated pill splitter to ensure an even cut down the middle.

All strengths of lisinopril tablets can be cut in half, so this includes:

  • Lisinopril 2.5 mg
  • Lisinopril 5mg
  • Lisinopril 10mg
  • Lisinopril 20mg
  • Lisinopril 30mg
  • Lisinopril 40mg

In your case, splitting the 40mg tablets you have to attain a dose of 20mg makes sense. I just recommend that you only cut one tablet at a time, and not all of them at once to store for later use since splitting tablets can sometimes make the split pieces more susceptible to moisture damage.

Alternatives To Splitting

If you don't want to go through the hassle of splitting tablets, you do have some alternative options.

Lisinopril is available in a variety of strengths (listed above), so they may be available in what your doctor has changed your dose to.

The tablets can also safely be crushed and sprinkled on top of food.

Lastly, it is available in a liquid form (Qbrelis 1mg/mL Solution), but currently, it is only available as a brand name, so it may not be covered by your insurance.

Final Words

I hope you found this helpful!

Reach back out anytime.


  • Tablet splitting: a review of weight and content uniformity, PubMed
  • Zestril Prescribing Information, AccessFDA

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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