Can You Take Aleve And Sudafed Together?
In our latest question and answer, the pharmacist discusses whether or not Aleve and Sudafed can be taken together.

Question
Hello, can Sudafed for sinus and Aleve for body ache be taken together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 19, 2025
Key points
- There is no known drug interaction between Aleve (naproxen) and Sudafed (pseudoephedrine).
- The active ingredients in Sudafed and Aleve can be found in a single pill (Aleve-D).
Answer
Yes, Sudafed (pseudoephedrine), can safely be taken with Aleve (naproxen). There is no drug interaction between the two.
In fact, these two drugs are available together in combination in a single product, Aleve-D Sinus & Cold.
It's not clear in your question if you are referring to Sudafed, which contains pseudoephedrine, or Sudafed PE, which contain phenylephrine. Regardless, Aleve can be taken with either drug safely and both represent an effective treatment for nasal congestion and other cold/flu symptoms.
If you are looking for Aleve-D at your local store, remember that you can only buy it at the pharmacy as it's stored behind the counter.
Aleve-D is an over-the-counter product and doesn't require a prescription but based on the regulations in the Combat Methamphetamine Epidemic Act, it needs to be stored securely and you need to show your ID for it.
What Is Aleve?
Naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches.
Naproxen is in a class of medications called NSAIDs and works by stopping the body's production of a substance that causes pain, fever, and inflammation. It is similar to ibuprofen, but has a longer duration of action (around 8 to 12 hours per dose).
What Is Sudafed?
Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure.
Pseudoephedrine is in a class of medications called nasal decongestants and works by causing narrowing of the blood vessels in the nasal passages.
Final Words
Thanks for your question! We are always happy to help.
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Dr. Brian Staiger, PharmD
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