Can You Take DayQuil With Allegra?

In our latest question and answer, the pharmacist discusses the use of Allegra and DayQuil together.

1 min read Updated Jun 2026 Read by 11,399 people
Can You Take DayQuil With Allegra?
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Paul asked

Hi, can I combine Allegra and DayQuil? Thanks for your help.

Jul 03, 2022
The quick answer
  • DayQuil and Allegra are safe to take together with no drug interaction between them.
  • DayQuil products do not contain an antihistamine, so they won't interact with Allegra's active ingredient fexofenadine.
  • Do not take NyQuil with Allegra since NyQuil contains an antihistamine that can interact with other antihistamines.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Hello and thanks for reaching out to us! It's always a good idea to look into whether or not certain drugs interact with one another.

The good news here is that DayQuil and Allegra are safe to take together. There is no drug interaction between them.

In fact, there are a variety of DayQuil products on the market, and Allegra is safe to take with all of them. DayQuil products include:

  • DayQuil Cold & Flu
  • DayQuil Severe
  • DayQuil HBP
  • DayQuil VapoCool
  • DayQuil Honey

Allegra contains the antihistamine fexofenadine. None of the DayQuil products listed above contain an antihistamine nor do they interact with any antihistamine.

It is important to note that NyQuil contains an antihistamine (doxylamine), and generally should not be taken with other antihistamines, which includes Allegra.

Thanks again for your question and please feel free to reach out to us again in the future.

References & sources
  1. Antihistamines and allergy — PubMed
  2. Fexofenadine Monograph — PubChem
  3. DayQuil Manufacturer — DayQuil
Glossary — Terms in This Answer
Drug interaction
A change in how a medication works when taken together with another drug, food, or substance.
Antihistamine
A medication that blocks the effects of histamine in the body to relieve allergy symptoms and itching.
Fexofenadine
The active ingredient in Allegra that works as an antihistamine to treat allergy symptoms.
Doxylamine
An antihistamine ingredient found in NyQuil that helps reduce coughing and promote sleep.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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