Can You Take Sudafed And NyQuil Together?

Answer

Great question! It's always a good idea to ask about taking multiple over-the-counter medications as many of them are combination products and contain more than one drug. You want to avoid doubling up on the same drug.

In regard to NyQuil and Sudafed (pseudoephedrine), they can safely be taken together as NyQuil does not already contain a decongestant and there are no interactions between any of the drugs. You can also take one in the morning and one in the evening as you suggested.

The 'original' NyQuil contains the following ingredients:

• Acetaminophen (pain reliever)
• Dextromethorphan (cough suppressant)
• Doxylamine (sedating antihistamine)

Watch Out For NyQuil Products That Contain A Decongestant Already

I do want to point out that although the 'original' NyQuil is safe to combine with Sudafed, NyQuil Severe, a different product in the NyQuil family of products, does contain a decongestant and should not be taken with Sudafed.

NyQuil Severe contains:

• Acetaminophen (pain reliever)
• Dextromethorphan (cough suppressant)
• Doxylamine (sedating antihistamine)
• Phenylephrine (decongestant)

Phenylephrine and Sudafed (pseudoephedrine) are similar drugs and both decongestants. They should not be used together.

Nasal Decongestants Should Be Used Cautiously In Those With High Blood Pressure

You mentioned in your question that you have high blood pressure.

Although data is mixed, studies report that nasal decongestants, like Sudafed, can raise blood pressure and put those with heart conditions at more risk of adverse events.

In general, it is recommended to avoid combining nasal decongestants if you have high blood pressure unless specifically recommended by your doctor. It is for this reason that there are a number of over-the-counter products that are marketed specifically for individuals with high blood pressure (they don't contain a decongestant).

One such product is in the NyQuil family, NyQuil HBP (high blood pressure).

Be Careful About Using Decongestants At Bedtime

Another point I want to bring up is that nasal decongestants can have a mild stimulating effect in some individuals and can sometimes cause insomnia. This is even highlighted on the 'Drug Facts' for oral nasal decongestant products, like Sudafed:

If you are having trouble sleeping, it is often recommended to not take a decongestant within at least a few hours of bedtime.

The sedative effects of NyQuil may slightly offset the stimulating effects of Sudafed, but it is an important point to keep in mind that Sudafed might not be doing you any favors if you are having issues falling asleep.

You mentioned in your question that you would be looking to take Sudafed during the day and NyQuil in the evening. This is a good plan to avoid the potential stimulating effects of Sudafed affecting your sleep.

Final Words

I hope you found this helpful! Reach back out again anytime.