I Accidentally Chewed My Metformin. Is That Okay?

In our latest question and answer, the pharmacist discusses the safety of accidentally chewing a metformin tablet.

Question

I was taking my medication with dinner and some chewable vitamins and accidentally chewed my metformin 500 tablet. It was not an ER type. Should I be concerned about it? This is for people who might accidentally do this in the future because I could not find an answer anywhere online. Thanks

Asked by Paja On Jul 04, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 05, 2023
Last updated Apr 30, 2024

Key points

  • Chewing an immediate-release metformin 500mg tablet should not cause any harm or affect its function, but it is not recommended due to taste and texture.
  • Chewing an extended-release metformin tablet can disrupt its mechanism and increase the risk of side effects. Extended-release metformin tablets should not be chewed, crushed or split.

Quick Answer

Chewing an immediate-release metformin tablet by mistake is unlikely to result in any harm or alter how the drug works. Nevertheless, it is advisable to avoid chewing metformin tablets due to their taste and texture.

There are other options available if you are finding the tablets difficult to swallow.

Detailed Answer

I'm sorry to hear you've had trouble getting your question answered but that's what we're here for! As always, we are more than happy to provide an answer here.

Metformin is an oral antidiabetic drug commonly used to manage high blood sugar levels in individuals with type 2 diabetes. It is available in a variety of dosage forms including:

  • Immediate-release tablets
  • Extended-release tablets (there are several different 'ER' forms available)
  • Liquid solution

As mentioned in the 'quick answer' section, chewing an immediate-release metformin 500mg tablet, though not recommended, should not have any significant negative effects on the medication's intended function.

However, it is important to note that immediate-release metformin tablets are not designed to be chewed. They are typically coated to make them easier to swallow and to improve their taste. Chewing the tablet can expose you to an unpleasant taste and texture, as metformin tablets can be somewhat chalky.

Additionally, the bitter taste of the medication may linger in your mouth, which can be unpleasant.

Again though, even though it won't taste good, you shouldn't expect any other negative consequences from having accidentally chewed your metformin immediate-release tablet.

Do Not Chew Extended-Release Metformin

It is worth mentioning that if you accidentally chewed an extended-release (ER) metformin tablet, the situation would be different.

ER formulations are designed to release the medication slowly over an extended period to provide a steady blood concentration and to improve tolerability.

Chewing an ER tablet can disrupt this mechanism and result in all the medication being released at once. If you mistakenly chew an ER metformin tablet, you are putting yourself at a greater risk of side effects.

Final Words

So, to reiterate, while accidentally chewing a non-extended-release metformin 500mg tablet should not cause any immediate harm or affect its intended function, it is best to avoid chewing the medication. You mentioned in your question this was a one-time accident, so it doesn't seem like you intend to keep on doing this.

I will say that if you have difficulty swallowing tablets, you may consider discussing alternative dosage forms (e.g., a liquid formulation or smaller-sized tablets) with your doctor. Immediate-release tablets too, can be crushed or split if necessary.

Thanks for reaching out to us and feel free to do so again anytime.

References

  • Glucophage Prescribing Information, AccessFDA
  • Fortamet Prescribing Information, AccessFDA

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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