I Accidentally Chewed My Metformin. Is That Okay?

In our latest question and answer, the pharmacist discusses the safety of accidentally chewing a metformin tablet.

2 min read Updated Jun 2026 Read by 2,262 people
I Accidentally Chewed My Metformin. Is That Okay?
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Paja asked

I was taking my medication with dinner and some chewable vitamins and accidentally chewed my metformin 500 tablet. It was not an ER type. Should I be concerned about it? This is for people who might accidentally do this in the future because I could not find an answer anywhere online. Thanks

Jul 04, 2023
The quick answer
  • Accidentally chewing an immediate-release metformin tablet won't harm you or change how the medication works, though it may taste unpleasant and chalky.
  • If you have trouble swallowing tablets, talk to your doctor about alternative forms like liquid metformin or smaller tablets, or ask if your immediate-release tablets can be crushed.
  • Never chew extended-release metformin tablets, as this can cause all the medication to release at once and increase your risk of side effects.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Quick Answer

Chewing an immediate-release metformin tablet by mistake is unlikely to result in any harm or alter how the drug works. Nevertheless, it is advisable to avoid chewing metformin tablets due to their taste and texture.

There are other options available if you are finding the tablets difficult to swallow.

Detailed Answer

here. Metformin commonly used to manage high blood sugar levels in individuals with type 2 diabetes. It is available in a variety of dosage forms including:

  • Immediate-release tablets
  • Extended-release tablets (there are several different 'ER' forms available)
  • Liquid solution

As mentioned in the 'quick answer' section, chewing an immediate-release metformin 500mg tablet, though not recommended, should not have any significant negative effects on the medication's intended function.

However, it is important to note that immediate-release metformin tablets are not designed to be chewed. They are typically coated to make them easier to swallow and to improve their taste. Chewing the tablet can expose you to an unpleasant taste and texture, as metformin tablets can be somewhat chalky.

unpleasant. Again though, even though it won't taste good, you shouldn't expect any other negative consequences from having accidentally chewed your metformin immediate-release tablet.

Do Not Chew Extended-Release Metformin

It is worth mentioning that if you accidentally chewed an extended-release (ER) metformin tablet, the situation would be different.

ER formulations are designed to release the medication slowly over an extended period to provide a steady blood concentration and to improve tolerability.

Chewing an ER tablet can disrupt this mechanism and result in all the medication being released at once. If you mistakenly chew an ER metformin tablet, you are putting yourself at a greater risk of side effects.

Final Words

So, to reiterate, while accidentally chewing a non-extended-release metformin 500mg tablet should not cause any immediate harm or affect its intended function, it is best to avoid chewing the medication. You mentioned in your question this was a one-time accident, so it doesn't seem like you intend to keep on doing this.

I will say that if you have difficulty swallowing tablets, you may consider discussing alternative dosage forms (e.g., a liquid formulation or smaller-sized tablets) with your doctor. Immediate-release tablets too, can be crushed or split if necessary.

Thanks for reaching out to us and feel free to do so again anytime.

References & sources
  1. Glucophage Prescribing Information — AccessFDA
  2. Fortamet Prescribing Information — AccessFDA
Glossary — Terms in This Answer
Immediate-release
A medication formulation designed to release the drug quickly into your bloodstream after you take it.
Metformin
An oral medication commonly prescribed to help control blood sugar levels in people with type 2 diabetes.
Antidiabetic drug
A medication used to treat diabetes by helping to lower and manage blood sugar levels.
Dosage forms
The different physical shapes and types in which a medication is available, such as tablets, liquids, or capsules.
Extended-release
A medication formulation designed to slowly release the drug over many hours to maintain steady medication levels in your body.
Blood concentration
The amount of medication present in your bloodstream at any given time.
Tolerability
How well a person's body can handle a medication without experiencing unwanted side effects.
Side effects
Unwanted or harmful reactions that occur when taking a medication in addition to its intended therapeutic effect.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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