Is Elderberry Safe To Take With Motrin?

In our latest question and answer, the pharmacist discusses whether or not lisinopril is safe to take with elderberry supplements.

3 min read Updated Jun 2026 Read by 3,499 people
Is Elderberry Safe To Take With Motrin?
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Sandy asked

Can you tell me if it is okay to mix elderberry supplements with Motrin?

Jul 07, 2022
The quick answer
  • There are no known interactions between elderberry and Motrin, so they are safe to take together.
  • Elderberry is considered generally safe by the FDA when used in typical amounts found in supplements and food.
  • Ibuprofen works by reducing pain, fever, and inflammation in the body.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Hello and thanks for reaching out to us! We're more than happy to help with potential drug interaction questions, especially where it involves herbal or supplements since there is a general lack of data available regarding those.

Based on published studies evaluating elderberry and what we know about Motrin (ibuprofen), there are no known or expected interactions between the drugs. They are considered safe to take together.

So, if you have cold or flu symptoms, and you want to take a supplement that contains elderberry, you can feel safe doing so. This also applies to elderberry products (i.e. Zarbee's Immune) with Children's Motrin. They are safe to combine.

What Is Elderberry?

Elderberry has a long history of use medically for its purported immune system enhancing effects. It is mostly marketed in over-the-counter supplements to help shorten the duration of colds and the flu. Although there have been relatively few studies testing how well it works in this regard, some small clinical studies have shown it can affect different components of the immune system (e.g. cytokines) and may have positive benefits in healthy adults and children. Other studies have shown no benefit, however. More rigorous studies are needed to better understand exactly the benefits it can have as a supplement.

Regardless, elderberry seems relatively safe to use in amounts that would commonly be found in food. In fact, it is 'generally recognized as safe' (GRAS) by the FDA.

There are no known drug interactions between elderberry and prescription or over-the-counter medications. Based on studies showing that it may have immunostimulating effects, it theoretically could interact with immunosuppressants, but this has not been shown clinically. Regardless, simply due to the lack of studies, it should not be combined with drugs that are supposed to suppress the immune system.

What Is Motrin?

Ibuprofen is available both over-the-counter (as 200mg) and as a prescription (as 400mg, 600mg and 800mg). It is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period).

Ibuprofen is classified as an NSAID (non-steroidal antiinflammatory drug) and works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Final Words

Thanks again for reaching out to us!

References & sources
  1. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines — PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe — AccessFDA
  3. Ibuprofen Monograph — PubChem
Glossary — Terms in This Answer
Drug interaction
When two or more medications affect each other's effectiveness or safety when taken together.
Cytokines
Signaling molecules in the immune system that help regulate inflammation and immune responses.
Immunosuppressants
Drugs that reduce the activity of the immune system to prevent rejection of transplants or treat autoimmune diseases.
Immunostimulating
Causing the immune system to become more active or responsive.
Osteoarthritis
Arthritis caused by wear and tear on the protective lining covering the ends of bones in joints.
Rheumatoid arthritis
Arthritis caused by the immune system attacking the lining of the joints, leading to swelling and pain.
NSAID
A class of pain-relieving and anti-inflammatory drugs that work by blocking substances in the body that cause pain and swelling.
Inflammation
Swelling, redness, and soreness that occur when the body responds to injury or infection.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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