Is It Safe To Use Zarbee's Cough And Delsym Together?
In our latest question and answer, the pharmacist discusses whether or not it is safe to combine Zarbee's with Delsym.

Question
Hi, my daughter has a nasty cough that seems to be due to a cold. We are treating her with Zarbee's and want to know if it is also okay to give Delsym syrup. Thanks!

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 03, 2025
Key points
- There is no known interaction between Delsym (dextromethorphan) and Zarbee's cough syrup.
Hello and thanks for reaching out! I'm sorry to hear your daughter is sick and I hope that she starts to feel better soon!
In regard to the medications you asked about in your question, Zarbee's cough syrup is safe to take along with Delsym. There are no known interactions between the two.
Even though both are considered 'cough syrups', they contain very different ingredients that do not interact with one another. In fact, most Zarbee's products have no known interactions with any over-the-counter medications as they simply contain 'non-drug' ingredients, such as honey, agave, vitamins, minerals and various botanicals.
What Is In Zarbee's Cough?
Zarbee's cough syrup contains:
- Dark Honey
- Grapefruit Seed Extract
- Ascorbic Acid
- Zinc Gluconate
- Water
- Citric Acid
- Natural Flavors
You'll notice there are no pharmaceutical drugs in Zarbee's cough syrup, unlike Delsym, which contains the cough medication dextromethorphan. Most Zarbee's products are actually considered 'supplements', which is why the labeling on the box has a section for 'Supplement Facts', and not 'Drug Facts'.
None of this is to say that Zarbee's isn't effective. Honey, for example, has a strong body of evidence that it can help reduce the severity of coughing associated with infection. Zarbee's cough syrup also contains Vitamin C and Zinc, which also have evidence for benefit.
Use Together
As previously stated, Zarbee's cough syrup can safely be used with Deslym (dextromethorphan). They don't interfere with one another.
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Dr. Brian Staiger, PharmD
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