Is Mobic (Meloxicam) Safe With Tylenol?
In our latest question and answer, the pharmacist discusses the safety of taking meloxicam with Tylenol.

Question
I take meloxicam every day for some arthritis. It is okay to take with Tylenol too?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 25, 2025
Key points
- There is no known drug interaction between Tylenol (acetaminophen) and Mobic (meloxicam).
Answer
Thanks for your question! Mobic (meloxicam) is safe to take with Tylenol (acetaminophen). There is no drug interaction between them.
While both Tylenol and meloxicam are pain relievers, they are in different drug classes and work in different ways. Additionally, studies show that the combination of an NSAID (which is what meloxicam is) and Tylenol can provide greater pain relief than either drug alone. In fact, there are NSAID/acetaminophen products available on the market, such as Advil Dual Action.
Tylenol Information
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Mobic Information
Meloxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve the pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older.
Meloxicam is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Final Words
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Dr. Brian Staiger, PharmD
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