Prednisone With Flexeril - Interaction Details
In our latest question and answer, our pharmacist discusses whether or not prednisone and Flexeril can safely be taken together.

Question
I have bronchitis and was prescribed prednisone. I take Flexeril off and on for muscle spasms. Are they okay together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Mar 10, 2025
Key points
- There is no known interaction between Flexeril (cyclobenzaprine) and prednisone.
Answer
There is no known interaction between prednisone and Flexeril (cyclobenzaprine). They are generally considered safe to take together.
Prednisone is a corticosteroid that is often used, among other things, to reduce inflammation in the body, while Flexeril is a muscle relaxant that is used to treat muscle spasms.
Prednisone is commonly prescribed for short-term use in treating inflammation in the airways caused by bronchitis. A similar steroid, Medrol, is often prescribed for this purpose as well (typically as a Medrol Dose Pack).
Both prednisone and cyclobenzaprine have different mechanisms of action and do not interfere with each other's metabolism or absorption.
Do They Have Shared Side Effects?
While these drugs don't share too many common side effects, they both have been reported to cause dizziness and heartburn, so that is important to be aware of.
The most common side effects of cyclobenzaprine include:
- Dry mouth
- Dizziness
- Nausea
- Constipation
- Heartburn
- Tiredness
The most common side effects of prednisone (when used for a short period of time) include:
- Headache
- Dizziness
- Difficulty falling asleep or staying asleep
- Mood changes
- Slowed healing of cuts and bruises
- Heartburn
- Increased sweating
Overall though, there isn't too much to be concerned about in regard to side effects being additive when these drugs are taken together.
Final Words
As always, it is important to follow your doctor's instructions regarding the dosing and timing of each medication to ensure optimal effectiveness and safety.
If you have any concerns or experience any adverse effects while taking these medications, it is important to contact your healthcare provider for further guidance.
Thanks so much for reaching out and feel free to do so again anytime!
Additional Resouces
Be sure to check out the drug information we have for both Flexeril and prednisone:
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Dr. Brian Staiger, PharmD
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