Taking Mucinex With Mitral Valve Problem And Several Heart Medications
In our latest question and answer, the pharmacist discusses if Mucinex is safe to take with several different medications and prior heart problems.

Question
I am 67 years old female with a heart problem (Mitral valve was replaced in 1997). My medications are warfarin 5mg, carvedilol 6.25 mg, tenofovir 300 mg, furosemide, and levothyroxine 200 mg. To relieve cough and mucus, can I take safely Mucinex 600 mg (guaifenesin) expectorant bi later tablets?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 10, 2025
Key points
- Mucinex is not thought to have clinically significant drug interactions.
- Mucinex is safe to use if you have had a mitral valve replacement.
Answer
Thanks so much for reaching out to us! Mucinex is safe to take in those with a prior mitral valve replacement, and with the medications you listed in your question, which are:
- Warfarin
- Carvedilol
- Tenofovir
- Furosemide
- Levothyroxine
In general, Mucinex (guaifenesin) is a very safe medication in terms of both potential drug interactions and side effects.
In fact, most drug resources report that Mucinex has no clinically significant interactions to be concerned about, and only causes mild side effects if they occur at all. These side effects include:
- Nausea
- Diarrhea
- Headache
Again, although these side effects can happen, they are quite uncommon at the usual dosages of Mucinex.
Additionally, there is no concern with using Mucinex if you have had a mitral valve replacement or prior heart issues. Mucinex does not raise blood pressure and is not known to increase the risk of any kind of cardiovascular complication.
Mucinex With Levothyroxine
The only thing I'll point out here in your medication list is taking levothyroxine with Mucinex. There is no drug interaction per se between them, but to ensure optimal absorption of your levothyroxine, you want to be sure to take it (levothyroxine) at least 30 minutes before food or other medication.
Taking levothyroxine inconsistently, or with other foods or medications can significantly alter how much you absorb of the drug, which could alter your thyroid levels. Just be sure to separate it from Mucinex.
Final Words
I hope this answer helped and reach back out anytime!
-
Dr. Brian Staiger, PharmD
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