Taking NyQuil With Amoxicillin

In our latest question and answer, the pharmacist discusses whether or not NyQuil can be taken with Amoxicillin.


Can you take NyQuil with amoxicillin?

Asked by Donald On Aug 11, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 11, 2022
Last updated Aug 11, 2022

Key points

  • Taking NyQuil and amoxicillin together is considered safe with no known drug interactions.
  • Your prescribed treatment regimen with amoxicillin should be finished completely and not stopped when you are feeling better unless directed by your doctor. NyQuil can be taken as needed.


Hello there and thanks for reaching out to us!

NyQuil is a multi-drug product used for the treatment of cold and flu symptoms. Amoxicillin is a penicillin antibiotic used to treat bacterial infections such as ear, nose, and throat infections, genitourinary tract infections, lower respiratory infections (like pneumonia), and skin infections.

NyQuil and amoxicillin may safely be taken together as there is no drug interaction between the two medications.

Below is some additional information on both NyQuil and amoxicillin.

NyQuil Cold & Flu Nighttime Relief

NyQuil Cold & Flu Nighttime Relief is a multi-drug product used in the treatment of cold and flu symptoms. It contains the following drugs:

  • Acetaminophen: Is a fever and pain reducer. Daily doses should not exceed 4 grams in adults.
  • Dextromethorphan: Is a cough suppressant used in the treatment of dry, unproductive coughs. It is usually a well-tolerated drug with drowsiness, stomach upsets, and nausea/vomiting being the most common side effects reported.
  • Doxylamine: Is a first-generation antihistamine used as a sleep aid and in the treatment of runny nose and sneezing. First-generation antihistamines are known to cause drowsiness. Besides drowsiness, other common side effects include dizziness, constipation, dry mouth and throat, blurred vision, and urinary retention. Caution should be taken if taken with other medications that are known to cause drowsiness or sedation.


Amoxicillin is a penicillin antibiotic. Antibiotics are used to treat bacterial infections but do not treat a cold or flu, which are caused by viruses. Patients with a known penicillin allergy should not use amoxicillin.

Some common side effects of amoxicillin include:

  • Nausea
  • Vomiting
  • Upset stomach
  • Diarrhea
  • Yeast infection

As with all antibiotics, the medication should be taken as directed and therapy completed fully even if the symptoms disappear before completion of the prescription. Stopping antibiotics before finishing the complete course of therapy can lead to bacterial resistance and make subsequent infections more difficult to treat.


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at Hello@HelloPharmacist.com! You can also connect with Dr. Brian Staiger on LinkedIn.

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