Taking Tylenol With Seroquel
In our latest question and answer, the pharmacist discusses whether or not Tylenol (acetaminophen) can safely be taken with Seroquel (quetiapine).
Is it okay to take Tylenol and Seroquel together? Thanks!
Jan 26, 2023- Seroquel and Tylenol have no known interactions and are safe to take together.
- Tylenol PM is not safe with Seroquel because it contains diphenhydramine, which can increase drowsiness when combined with Seroquel.
Answer
Thanks for reaching out! It is safe to take Seroquel (quetiapine) with Tylenol (acetaminophen). There are no known interactions between the two medications.
What About Other Pain Relievers?
Most pain relievers are safe with Seroquel. This includes:
- Advil (ibuprofen)
- Motrin (ibuprofen)
- Aleve (naproxen)
- Aspirin
As mentioned above, Tylenol is safe too although I do want to mention that Tylenol is a pain reliever contained in many different products so when I say Tylenol is safe, I am referring only to acetaminophen (the active ingredient).
As an example here, Tylenol PM contains acetaminophen and diphenhydramine. While acetaminophen is safe, diphenhydramine with Seroquel can increase the feeling of sedation and the combination needs to be used cautiously together.
Final Words
I hope you found this helpful! As always, thanks for using us!
References & sources
Glossary — Terms in This Answer
- Seroquel
- A prescription medication (quetiapine) used to treat conditions like bipolar disorder and schizophrenia.
- Quetiapine
- The generic chemical name for the drug Seroquel.
- Interactions
- Unwanted effects that occur when two or more medications are taken together and affect how each other works.
- Acetaminophen
- The active ingredient in Tylenol, a pain reliever and fever reducer.
- Ibuprofen
- A type of pain reliever and anti-inflammatory medication sold under brand names like Advil and Motrin.
- Naproxen
- A pain reliever and anti-inflammatory medication sold under the brand name Aleve.
- Diphenhydramine
- An antihistamine ingredient that causes drowsiness, found in products like Tylenol PM.
- Sedation
- A state of drowsiness or reduced alertness caused by medication.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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