Taking Metoprolol & Lisinopril/HCTZ Together
In our latest question and answer, our pharmacist discusses whether or not metoprolol can safely be taken with lisinopril/HCTZ.

Question
Should I be taking metoprolol succinate ER and Lisinopril-HCTZ together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 04, 2025
Key points
- There is no drug interaction between metoprolol and lisinopril/HCTZ. It is important to be aware though that when first starting them, they can cause dizziness and drowsiness.
- Depending on your condition, your doctor may prescribe you multiple blood pressure medications from different drugs classes.
Answer
Yes, metoprolol & lisinopril/hydrochlorothiazide can be taken together. There as no drug interactions between the two.
In fact, this combination of medications (a beta-blocker, an ACE-Inhibitor, and a diuretic) is recommended for certain conditions.
For example, the American Society of Hypertension (ASH) recommends the combination of a beta blocker (e.g. metoprolol) along with an ACE-Inhibitor (e.g. lisinopril) for the treatment of coronary artery disease. Thiazide diuretics (e.g. HCTZ) are also recommended agents for certain individuals.
All of these medications too you may see prescribed to someone who has had a previous heart attack.
Being On Multiple 'Blood Pressure Medications' Is Common
When treating uncomplicated hypertension (blood pressure), multiple classes of drugs are typically added together until blood pressure is adequately controlled. It is not uncommon to see patients on 3 or 4 different classes of blood pressure medications.
There are many other indications that could call for the combination you are taking and is commonplace. If you have concerns about your current therapy, be sure to bring up your questions to your doctor.
If one of these medications is new to you, be aware that it could cause dizziness and lightheadedness, at least initially. This isn't a drug interaction, but your body is adjusting to lower blood pressure.
Final Words
Thanks for your question and be sure to reach out again in the future!
References
- 2022 ACC/AHA Key Data Elements and Definitions for Chest Pain and Acute Myocardial Infarction: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Data Standards, AHA Journals
- 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, AHA Journals
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Dr. Brian Staiger, PharmD
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