Taking Metoprolol & Lisinopril/HCTZ Together
In our latest question and answer, our pharmacist discusses whether or not metoprolol can safely be taken with lisinopril/HCTZ.
Should I be taking metoprolol succinate ER and Lisinopril-HCTZ together?
Oct 25, 2022- Metoprolol and lisinopril/HCTZ can be safely taken together with no drug interactions between them.
- This three-drug combination is commonly recommended for blood pressure control and certain heart conditions like coronary artery disease.
- You may experience dizziness or lightheadedness when starting these medications as your body adjusts to lower blood pressure.
Answer
Yes, metoprolol & lisinopril/hydrochlorothiazide can be taken together. There are no drug interactions between the two.
In fact, this combination of medications (a beta-blocker, an ACE-Inhibitor, and a diuretic) is recommended for certain conditions.
For example, the American Society of Hypertension (ASH) recommends the combination of a beta blocker (e.g. metoprolol) along with an ACE-Inhibitor (e.g. lisinopril) for the treatment of coronary artery disease. Thiazide diuretics (e.g. HCTZ) are also recommended agents for certain individuals.
All of these medications too you may see prescribed to someone who has had a previous heart attack.
Being On Multiple 'Blood Pressure Medications' Is Common
When treating uncomplicated hypertension (blood pressure), multiple classes of drugs are typically added together until blood pressure is adequately controlled. It is not uncommon to see patients on 3 or 4 different classes of blood pressure medications.
There are many other indications that could call for the combination you are taking and is commonplace. If you have concerns about your current therapy, be sure to bring up your questions to your doctor.
If one of these medications is new to you, be aware that it could cause dizziness and lightheadedness, at least initially. This isn't a drug interaction, but your body is adjusting to lower blood pressure.
Final Words
Thanks for your question and be sure to reach out again in the future!
References & sources
- 2022 ACC/AHA Key Data Elements and Definitions for Chest Pain and Acute Myocardial Infarction: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Data Standards — AHA Journals
- 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines — AHA Journals
Glossary — Terms in This Answer
- Beta-blocker
- A type of medication that slows your heart rate and reduces blood pressure by blocking certain nerve signals.
- ACE-Inhibitor
- A blood pressure medication that works by relaxing blood vessels to help blood flow more easily.
- Diuretic
- A medication that helps your body remove excess water and salt through urine to lower blood pressure.
- Thiazide diuretics
- A specific class of water pills commonly used to treat high blood pressure and reduce fluid in the body.
- Coronary artery disease
- A condition where the arteries that supply blood to the heart become narrowed or blocked.
- Drug interactions
- Harmful effects that can occur when two or more medications react with each other in your body.
- Hypertension
- High blood pressure, a condition where the force of blood against artery walls is consistently too high.
- Indications
- Medical reasons or conditions for which a particular medication or treatment is recommended.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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