Medication interaction hub

What Supplements Interact with Lisinopril?

Lisinopril brand names: Zestril, Prinivil, Qbrelis. Every interaction below applies to the brands too.

167 Interactions 6 Major 137 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lisinopril? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lisinopril against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lisinopril is an ACE inhibitor that lowers blood pressure and protects the heart and kidneys, so the 167 supplements and herbs on this page warrant genuine care. Six carry a major rating, and those deserve your attention first. Most of the rest (137 moderate, 24 minor) act on blood pressure themselves, either dropping it further than intended or pushing it back up and undoing the prescription. Potassium is the everyday standout, since lisinopril already helps the body hold onto potassium and adding more can raise levels dangerously.

Smaller clusters matter too. A few herbs can stress the kidneys, the same organ lisinopril depends on, and some of the majors sit in that group. Others, activated charcoal among them, can soak up an oral dose before it absorbs, so space those well apart. Around twenty add sun sensitivity. Start with the six major entries below and read them closely.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 137 Minor 24 No known interaction 1,285

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lisinopril: Top Interactions at a Glance

The Lisinopril supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 167 interacting ingredients — plus 1,285 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lisinopril Combinations Today

The Lisinopril + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Seed + Lisinoprili

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Berberine + Lisinoprili

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Docosahexaenoic Acid (dha) + Lisinoprili

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Green Tea + Lisinoprili

Theoretically, green tea might reduce the levels and clinical effects of lisinopril.

Read the full interaction Minor Likelihood Unlikely Capsicum + Lisinoprili

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Read the full interaction Minor Likelihood Possible Fenugreek + Lisinoprili

Fenugreek may also have an additive effect on blood pressure-lowering medications.

Read the full interaction
The complete list

Every Supplement Checked Against Lisinopril

All 1,452 ingredients in our database, ranked by severity — 167 with a Lisinopril interaction on file and 1,285 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lisinopril?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Lisinopril answer

Can you take Berberine with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Lisinopril answer

Can you take Docosahexaenoic Acid (dha) with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Lisinopril answer

Can you take Green Tea with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the levels and clinical effects of lisinopril.

Full Green Tea + Lisinopril answer

Can you take Capsicum with Lisinopril?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.

Full Capsicum + Lisinopril answer

Can you take Guarumo with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intrav...

Full Guarumo + Lisinopril answer

Can you take Gum Arabic with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Lisinopril answer

Can you take Hesperidin with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.

Full Hesperidin + Lisinopril answer

Can you take Hibiscus Sabdariffa with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antihypertensive drugs might increase the risk of hypotension.

Full Hibiscus Sabdariffa + Lisinopril answer

Can you take Hoodia with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research shows that hoodia can increase blood pressure.

Full Hoodia + Lisinopril answer

Can you take Horny Goat Weed with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Lisinopril answer

Can you take Indian Snakeroot with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot and antihypertensive drugs might increase the risk of hypotension.

Full Indian Snakeroot + Lisinopril answer

Can you take Isopropylnorsynephrine with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.

Full Isopropylnorsynephrine + Lisinopril answer

Can you take Khat with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Full Khat + Lisinopril answer

Can you take Khella with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Lisinopril answer

Can you take Kiwi with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Lisinopril answer

Can you take Korean Pine with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.

Full Korean Pine + Lisinopril answer

Can you take L-citrulline with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotensio...

Full L-citrulline + Lisinopril answer

Can you take Laminaria with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.

Full Laminaria + Lisinopril answer

Can you take Licorice with Lisinopril?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might reduce the effects of antihypertensive drugs.

Full Licorice + Lisinopril answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lisinopril is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lisinopril, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lisinopril sits in 6 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Lisinopril through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Lisinopril through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lisinopril through this category.

Ace Inhibitors (Aceis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Lisinopril through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Lisinopril through this category.

Lisinopril 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lisinopril through this category.

About Lisinopril

Lisinopril is an ACE inhibitor used to treat high blood pressure, heart failure, and improve survival after a heart attack.

Generic name: Lisinopril  ·  Brand names: Zestril, Prinivil, Qbrelis.

See the full Lisinopril drug information

Related: does Lisinopril deplete any nutrients?

Lisinopril has 3 reported nutrient associations in the research literature — see the Lisinopril nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lisinopril

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lisinopril.

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Pharmacist Counseling Corner

Lisinopril & Supplements: Common Questions

What supplements interact with Lisinopril?
More than you might expect — 167 in total, though they are far from equal: 6 are rated major, 137 moderate, and 24 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Lisinopril supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lisinopril?
Usually yes — most people on Lisinopril can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zestril have the same supplement interactions as Lisinopril?
Yes — Zestril, Prinivil, Qbrelis all contain Lisinopril, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lisinopril deplete any vitamins or nutrients?
It might — Lisinopril has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lisinopril nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lisinopril and my other medications?
This page covers Lisinopril against supplements and herbal ingredients. Checking Lisinopril against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lisinopril drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.