Drug & supplement interaction

Papaya + Lisinopril

Lisinopril brand names: Zestril, Prinivil, Qbrelis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Papaya and Lisinopril in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Papaya and Lisinopril

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lisinopril and Papaya in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Papaya safety at a glance

Papaya overall Use caution Ripe fruit is generally safe as food, but concentrated supplements and unripe papaya are less well studied.
Pregnancy Likely Safe When the ripe fruit is consumed in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When the ripe fruit is consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of using papaya medici... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lisinopril and Papaya? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lisinopril

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lisinopril is filed under 6 classifications — including ace inhibitors (aceis), antihypertensive drugs, photosensitizing drugs. Papaya has documented interactions with 4 drug classes — the most serious being amiodarone (cordarone) (moderate), antidiabetes drugs (moderate) and levothyroxine (synthroid, others) (moderate) — and none of Lisinopril’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Papaya Does Interact With Other Medications

Papaya has 92 moderate known drug interactions in our database — Lisinopril isn’t one of them. If you take anything else, check it against the full list below.

Moderate 92 No known interaction 2,738 (incl. Lisinopril)
Taking anything else?

Check Another of Your Medications Against Papaya

Covers the 2,830 medications we’ve checked against Papaya. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Papaya and Lisinopril May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Papaya

    “Orally, papain, a constituent of raw, unripe papaya, has been reported to cause allergic reactions in sensitive individuals, including itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea (6,967). Papaya may also cause hypersensitivity reactions such as systemic contact dermatitis, which occur more commonly in people who are allergic to latex.”

    Papaya · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 967. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
    3. 6197. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
    4. 7853. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
    5. 57635. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
    6. 67942. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed

    Lisinopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Lisinopril. Read the label on DailyMed ›

  • A stuffy or runny nose / Sweating / Stomach pain / Diarrhea / A skin rash reported in 5.7% of FDA reports for Lisinopril Additional detail

    Papaya

    Recorded for Papaya in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Lisinopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Lisinopril, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea / Vomiting reported in 6.1% of FDA reports for Lisinopril Additional detail

    Papaya

    “Orally, the leaf extract has been reported to cause nausea and vomiting in clinical research. A case of esophageal perforation has been reported for a previously healthy 27-year-old female who used papain, a constituent of papaya latex, to digest a piece of meat stuck in her esophagus.”

    Papaya · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 102799. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed
    2. 93083. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed

    Lisinopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Lisinopril, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Lisinopril come from the ADVERSE REACTIONS section of its FDA label; effects for Papaya come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 313,746 voluntary FDA FAERS reports for Lisinopril that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Papaya in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When the ripe fruit is consumed in amounts commonly found in foods.

Pregnancy Possibly Unsafe

When the unripe fruit containing papaya latex is used orally; avoid using. There is some concern that crude papain, a constituent of papaya latex, is teratogenic and embryotoxic; however, this might be due to extraneous substances rather than papain. Some evidence also suggests that high doses of papaya seed extract have abortifacient activity and can adversely affect fetal development. Theoretically, eating large amounts of papaya seeds may have similar effects.

Lactation Likely Safe

When the ripe fruit is consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of using papaya medicinally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Papaya or Lisinopril

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Papaya or Lisinopril, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lisinopril

This page covers Papaya only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lisinopril page lists 167 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 137 moderate · 24 minor.

From our pharmacist’s overview on the Lisinopril page

“Lisinopril is an ACE inhibitor that lowers blood pressure and protects the heart and kidneys, so the 167 supplements and herbs on this page warrant genuine care. Six carry a major rating, and those deserve your attention first.”

Reviewed by 2 · Jul 18, 2026

Open the Lisinopril interaction page

One more smart check

Taking Papaya as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,801 real supplement products containing Papaya, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Papaya. Even though Papaya itself has no known interaction with Lisinopril, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Papaya and Lisinopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Papaya
Top 25%

#182 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lisinopril
Top 1%

#26 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Papaya reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Papaya and Lisinopril records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Papaya

What is Papaya?

Papaya
  • Digestive upset and indigestion
  • Constipation
  • Wound and skin care (topical)
  • Intestinal parasites (traditional)
  • Supporting platelet counts in dengue (investigational)

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is being studied for raising platelet counts in dengue fever, but most other supplement uses have limited human evidence. Talk to your pharmacist or doctor before using concentrated papaya supplements, and avoid unripe (green) papaya and papaya seed products in pregnancy.

Carica papaya · Caricaceae · Fruit (ripe and unripe), leaves, seeds, and the latex (source of papain) · Fresh fruit, juice, dried leaf, leaf extract or tea, capsules, tablets, fermented papaya preparations, and topical products

An interaction check asks whether these two react with each other — it does not ask whether Papaya is a good idea for someone in your situation. Here is what our Papaya record says about it on its own.

Papaya: dosing

There is no official, standardized dose of papaya for any health condition. The amount of active compounds varies a lot between fresh fruit, juice, leaf extracts, and capsule products.If you choose to use a papaya supplement, the safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Papaya monograph — the full record covers uses, side effects and every documented interaction.

Read the full Papaya monograph & all interactions
Medication

About Lisinopril

What Is Lisinopril Used For?

Brand names: Zestril, Prinivil, Qbrelis

Lisinopril treats high blood pressure (hypertension) in adults and children 6 years and older, and can be used alone or alongside other blood pressure medicines. Lowering blood pressure reduces the risk of strokes and heart attacks. The tablet combination product containing lisinopril and hydrochlorothiazide is specifically indicated for high blood pressure.

Lisinopril is also used as an add-on therapy to reduce signs and symptoms of systolic heart failure, and to reduce the risk of death in people who are hemodynamically stable (have reasonably stable circulation) within 24 hours of an acute heart attack (acute myocardial infarction).

Most-Reported Side Effects for Lisinopril

From FAERS, the FDA’s public side-effect reporting system (313,746 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,515 reports
Nausea 19,130 reports
Diarrhea 17,858 reports
Dyspnea 14,363 reports
Dizziness 13,969 reports
See full Lisinopril drug information
Keep checking

Other Drugs & Papaya

Browse every other medication we’ve checked against Papaya — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
92Moderate
0Minor
2,737No known interaction
92 Moderate 2,737 No interaction
Moderate

92 interactions

Showing 60 of 92 moderate interactions — see all 92 on the Papaya page.

No interaction 2,737 drugs checked — show the list

We also checked Papaya against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,737 medications checked with no known interaction — see the full Papaya list.

See the full Papaya interactions page
See every supplement checked against Lisinopril, ranked by severity
Evidence & sources

Papaya References

The 14 references that drive our Papaya monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Papaya and Lisinopril Together: Common Questions

Is it safe to take Papaya with Lisinopril?
We do not list a known interaction between Papaya and Lisinopril. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Papaya and Lisinopril have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Papaya and Lisinopril combination checked?
Interactions in our licensed database are recorded against drug classes. Lisinopril is filed under 6 classifications, and Papaya has documented interactions with 4 drug classes — none of Lisinopril's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Papaya interact with any other medications?
Yes. Papaya has 92 documented drug interactions in our database — Lisinopril is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lisinopril interact with any supplements?
Yes. Lisinopril has documented interactions with 167 supplements in our database — Papaya is not one of them. The Lisinopril interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Papaya monograph Uses, safety profile, and every drug interaction in one place Lisinopril drug information The full plain-English guide to this medication Lisinopril supplement interactions Every supplement checked against Lisinopril, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lisinopril and Papaya?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.