Drug & supplement interaction

Streptococcus Thermophilus + Lisinopril

Lisinopril brand names: Zestril, Prinivil, Qbrelis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Streptococcus Thermophilus and Lisinopril in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Streptococcus Thermophilus and Lisinopril

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lisinopril and Streptococcus Thermophilus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Streptococcus Thermophilus at all — not against Lisinopril, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Streptococcus Thermophilus safety at a glance

Streptococcus Ther... overall Use caution Generally well tolerated in healthy people, but people with weakened immune systems should be careful.
Pregnancy Possibly Safe When used orally and appropriately, short-term. A combination of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium animalis, and Lactobacil... Read the full pregnancy detail
Breastfeeding Use caution Limited safety data on supplements; food sources are generally considered acceptable, but ask your provider first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lisinopril and Streptococcus Thermophilus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Streptococcus Thermophilus and Lisinopril May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Streptococcus Thermophilus

    “Since many probiotic preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Bacteremia and sepsis have been reported in patients with indwelling or central venous catheters or patients who are severely ill and/or immunocompromised, including preterm infants, that were using probiotic products.”

    Streptococcus Thermophilus · Natural Medicines adverse-effect record, reported in prematurity.

    6 sources cited
    1. 4380. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
    2. 8561. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
    3. 13008. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
    4. 13070. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
    5. 90298. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
    6. 102416. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.

    Lisinopril

    Listed in the ADVERSE REACTIONS section of the FDA label for Lisinopril. Read the label on DailyMed ›

Effects for Lisinopril come from the ADVERSE REACTIONS section of its FDA label; effects for Streptococcus Thermophilus come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 313,746 voluntary FDA FAERS reports for Lisinopril that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Streptococcus Thermophilus in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately, short-term. A combination of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium animalis, and Lactobacillus delbrueckii has been used with apparent safety for 8 weeks starting at 24-28 weeks gestation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Streptococcus Thermophilus or Lisinopril

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Streptococcus Thermophilus or Lisinopril, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lisinopril

This page covers Streptococcus Thermophilus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lisinopril page lists 167 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 137 moderate · 24 minor.

From our pharmacist’s overview on the Lisinopril page

“Lisinopril is an ACE inhibitor that lowers blood pressure and protects the heart and kidneys, so the 167 supplements and herbs on this page warrant genuine care. Six carry a major rating, and those deserve your attention first.”

Reviewed by 2 · Jul 18, 2026

Open the Lisinopril interaction page

One more smart check

Taking Streptococcus Thermophilus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,450 real supplement products containing Streptococcus Thermophilus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Streptococcus Thermophilus. Even though Streptococcus Thermophilus itself has no known interaction with Lisinopril, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Streptococcus Thermophilus and Lisinopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Streptococcus Thermophilus
Top 25%

#191 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lisinopril
Top 1%

#26 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Streptococcus Thermophilus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Streptococcus Thermophilus and Lisinopril records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Streptococcus Thermophilus

What is Streptococcus Thermophilus?

  • Digestive health
  • Lactose intolerance
  • Diarrhea prevention and support
  • Gut microbiome balance
  • Immune support

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may help with digestion and lactose breakdown, but solid evidence for most specific health claims is still limited. Talk with your pharmacist or doctor before starting it, especially if your immune system is weak.

Streptococcus thermophilus · Streptococcaceae · Live bacterial cells (probiotic culture) · Capsules, powders, probiotic blends, yogurt, fermented dairy products

An interaction check asks whether these two react with each other — it does not ask whether Streptococcus Thermophilus is a good idea for someone in your situation. Here is what our Streptococcus Thermophilus record says about it on its own.

Streptococcus Thermophilus: dosing

There is no single official or standardized dose for Streptococcus thermophilus. Probiotic products are usually measured in colony-forming units (CFU), and amounts vary widely between products.The best approach is to follow the dosing directions on the product label, since formulas differ.

From our Streptococcus Thermophilus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Streptococcus Thermophilus monograph & all interactions
Medication

About Lisinopril

What Is Lisinopril Used For?

Brand names: Zestril, Prinivil, Qbrelis

Lisinopril treats high blood pressure (hypertension) in adults and children 6 years and older, and can be used alone or alongside other blood pressure medicines. Lowering blood pressure reduces the risk of strokes and heart attacks. The tablet combination product containing lisinopril and hydrochlorothiazide is specifically indicated for high blood pressure.

Lisinopril is also used as an add-on therapy to reduce signs and symptoms of systolic heart failure, and to reduce the risk of death in people who are hemodynamically stable (have reasonably stable circulation) within 24 hours of an acute heart attack (acute myocardial infarction).

Most-Reported Side Effects for Lisinopril

From FAERS, the FDA’s public side-effect reporting system (313,746 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,515 reports
Nausea 19,130 reports
Diarrhea 17,858 reports
Dyspnea 14,363 reports
Dizziness 13,969 reports
See full Lisinopril drug information
Keep checking

Other Drugs & Streptococcus Thermophilus

Browse every other medication we’ve checked against Streptococcus Thermophilus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Streptococcus Thermophilus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Streptococcus Thermophilus list.

See the full Streptococcus Thermophilus interactions page
See every supplement checked against Lisinopril, ranked by severity
Evidence & sources

Streptococcus Thermophilus References

The 21 references that drive our Streptococcus Thermophilus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Mehrabi Y, Abbasi MM. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33:25. PubMed
  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  13. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  14. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  15. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Streptococcus Thermophilus and Lisinopril Together: Common Questions

Is it safe to take Streptococcus Thermophilus with Lisinopril?
We do not list a known interaction between Streptococcus Thermophilus and Lisinopril. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Streptococcus Thermophilus and Lisinopril have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Lisinopril interact with any supplements?
Yes. Lisinopril has documented interactions with 167 supplements in our database — Streptococcus Thermophilus is not one of them. The Lisinopril interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Streptococcus Thermophilus monograph Uses, safety profile, and every drug interaction in one place Lisinopril drug information The full plain-English guide to this medication Lisinopril supplement interactions Every supplement checked against Lisinopril, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lisinopril and Streptococcus Thermophilus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.