Amoxicillin With Zestoretic Interaction

Answer

I'm not sure where you read of a drug interaction between amoxicillin and Zestoretic (lisinopril; hydrochlorothiazide), but they are considered safe to take together. Zestoretic will not reduce the effectiveness of amoxicillin in treating your urinary tract infection.

If you did read about an interaction, I imagine it would be only a theoretical one based on the fact that Zestoretic contains the diuretic hydrochlorothiazide.

Diuretics Interact With Some Drugs

Diuretics like hydrochlorothiazide cause diuresis (increased production of urine from the kidney) which, in theory, increases the excretion rate of some drugs that are predominately eliminated via the kidneys.

Additionally, some drugs are reabsorbed via the kidneys and diuresis would decrease this reabsorption, leading to an overall reduction in drug levels.

So, diuretics absolutely do interact with some drugs in several different ways, such as increased excretion and decreased reabsorption. However, this doesn't appear to be an issue when it comes to amoxicillin.

Amoxicillin With Diuretics

I'm guessing whatever interaction checker you looked at automatically showed an interaction between amoxicillin and Zestoretic simply based on the fact that you were checking a combination of a diuretic (hydrochlorothiazide) with a drug (amoxicillin) that is primarily excreted via the kidney.

However, taking amoxicillin with hydrochlorothiazide has not been shown to affect drug concentrations, or how well it works.

Amoxicillin is rapidly absorbed after taking a dose, and peak concentrations are reached after only 1 to 2 hours. It doesn't rely on kidney reabsorption to work and, in those with normal kidney function, more than 60% of an amoxicillin dose is excreted unchanged in the urine anyway.

Now, there are some documented minor interactions between amoxicillin and other diuretics, including:

• Furosemide
• Amiloride

Furosemide has been reported to cause small increases in amoxicillin concentrations while amiloride may decrease concentrations by inhibiting absorption in the intestines. In general, though, these are often reported as only minor interactions.

As mentioned, there have been no reported interactions between amoxicillin and hydrochlorothiazide (one of the components in Zestoretic).

Final Words

I hope you found this answer helpful!

If you'd like, you're more than welcome to write back and provide some specifics on where you read about the interaction and I would be happy to provide more context.

Thanks for reaching out!