Drug & supplement interaction

Polydextrose + Bevacizumab-Awwb

Bevacizumab-Awwb brand name: Mvasi.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Polydextrose and Bevacizumab-Awwb in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Polydextrose and Bevacizumab-Awwb

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bevacizumab-Awwb and Polydextrose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Polydextrose at all — not against Bevacizumab-Awwb, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Polydextrose safety at a glance

Polydextrose overall Generally safe Generally recognized as safe in foods for most people when consumed in normal amounts.
Pregnancy Use caution Amounts found in foods are likely fine, but check with your doctor before using supplement-level doses.
Breastfeeding Use caution Food amounts are likely fine, but data on concentrated supplement doses are limited.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bevacizumab-Awwb and Polydextrose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Polydextrose and Bevacizumab-Awwb May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation Additional detail

    Polydextrose

    “Orally, polydextrose may cause gas, bloating, and loose stools. These adverse effects are more common when single doses of more than 50 grams or daily doses of more than 90 grams are used. Higher doses of polydextrose (90 grams/day or more) may also cause transient diarrhea in some people.”

    Polydextrose · Natural Medicines adverse-effect record, reported in constipation.

    5 sources cited
    1. 27194. Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. PubMed
    2. 27208. Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258.
    3. 27212. Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. PubMed
    4. 27193. Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. PubMed
    5. 106527. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

    Bevacizumab-Awwb

    Listed in the ADVERSE REACTIONS section of the FDA label for Bevacizumab-Awwb. Read the label on DailyMed ›

  • Dizziness Additional detail

    Polydextrose

    “Orally, one participant in one clinical study complained of transient dizziness after eating yogurt containing polydextrose 12.5 grams.”

    Polydextrose · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 98660. Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-contro

    Bevacizumab-Awwb

    Listed in the ADVERSE REACTIONS section of the FDA label for Bevacizumab-Awwb. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Polydextrose

    “Orally, polydextrose seems to be well tolerated when used in doses of less than 50 grams.

    Most Common Adverse Effects:

    Orally: Bloating, diarrhea, gas.”

    Polydextrose · Natural Medicines adverse-effect record, reported in diarrhea.

    Bevacizumab-Awwb

    Listed in the ADVERSE REACTIONS section of the FDA label for Bevacizumab-Awwb. Read the label on DailyMed ›

  • A skin rash Additional detail

    Polydextrose

    “Orally, giving a formula supplemented with 4 grams/L of polydextrose and galacto-oligosaccharides (GOS) (1:1 ratio) to infants has been associated with an increased incidence of atopic dermatitis in one clinical study. However, it is unclear if this was due to polydextrose, GOS, or the combination.”

    Polydextrose · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 26709. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed

    Bevacizumab-Awwb

    Listed in the ADVERSE REACTIONS section of the FDA label for Bevacizumab-Awwb. Read the label on DailyMed ›

Reported for Polydextrose but not commonly for Bevacizumab-Awwb: bloating or gas.

Effects for Bevacizumab-Awwb come from the ADVERSE REACTIONS section of its FDA label; effects for Polydextrose come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Bevacizumab-Awwb

This page covers Polydextrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bevacizumab-Awwb page lists 1 supplement it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Pawpaw (minor).

By severity: 1 minor.

From our pharmacist’s overview on the Bevacizumab-Awwb page

“Bevacizumab-awwb (Mvasi) is an IV cancer drug, a biosimilar of bevacizumab, used against colorectal, lung, and other tumors by cutting off the blood supply they need. Given how serious that treatment setting is, the supplement record here is strikingly short.”

Reviewed by 2 · Jul 18, 2026

Open the Bevacizumab-Awwb interaction page

One more smart check

Taking Polydextrose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 37 real supplement products containing Polydextrose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Polydextrose. Even though Polydextrose itself has no known interaction with Bevacizumab-Awwb, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Polydextrose and Bevacizumab-Awwb Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Polydextrose
Top half

#517 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bevacizumab-Awwb
Top half

#1,193 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Polydextrose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Polydextrose and Bevacizumab-Awwb records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Polydextrose

What is Polydextrose?

  • Adding dietary fiber
  • Supporting digestive regularity
  • Sugar and fat replacement in foods
  • Promoting gut bacteria (prebiotic)
  • Helping with calorie reduction

Polydextrose is a man-made soluble fiber used widely in foods as a low-calorie bulking agent and prebiotic. It is generally well tolerated, though large amounts can cause gas, bloating, or loose stools. It is not a medicine and should not replace a balanced, fiber-rich diet.

Synthetic carbohydrate made from glucose (dextrose), sorbitol, and citric acid · Added to foods and drinks (baked goods, low-calorie products), powders, fiber supplements

An interaction check asks whether these two react with each other — it does not ask whether Polydextrose is a good idea for someone in your situation. Here is what our Polydextrose record says about it on its own.

Polydextrose: dosing

There is no official medicinal dose for polydextrose, since it is mainly used as a food ingredient rather than a medicine. The amount you get depends on the foods or supplements you choose.If you use a product that contains polydextrose, follow the directions on the label. As with any fiber, it is best to start with a small amount and increase gradually while drinking plenty of water.

From our Polydextrose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Polydextrose monograph & all interactions
Medication

About Bevacizumab Injection

What Is Bevacizumab Injection Used For?

Brand name: Mvasi

Bevacizumab injection is used to treat multiple types of advanced or metastatic cancers, most often in combination with chemotherapy. Avastin is approved for metastatic colorectal cancer (when combined with specific fluorouracil-based chemotherapy regimens), non-squamous non-small cell lung cancer (first-line, with carboplatin and paclitaxel), recurrent glioblastoma in adults, metastatic renal cell carcinoma (with interferon alfa), persistent or metastatic cervical cancer, and hepatocellular carcinoma (liver cancer, in combination with atezolizumab for patients who have not yet received systemic therapy).

Avastin is also approved for epithelial ovarian, fallopian tube, or primary peritoneal cancer — including stage III/IV disease after surgery, platinum-resistant recurrent disease, and platinum-sensitive recurrent disease — each with specific chemotherapy partner regimens. Note that Avastin is not indicated for adjuvant (preventive post-surgery) treatment of colon cancer.

See full Bevacizumab Injection drug information
Keep checking

Other Drugs & Polydextrose

Browse every other medication we’ve checked against Polydextrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Polydextrose References

The 7 references that drive our Polydextrose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
  2. Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. PubMed
  3. Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. PubMed
  4. Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258.
  5. Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. PubMed
  6. Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-contro
  7. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Polydextrose and Bevacizumab-Awwb Together: Common Questions

Is it safe to take Polydextrose with Bevacizumab-Awwb?
We do not list a known interaction between Polydextrose and Bevacizumab-Awwb. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Polydextrose and Bevacizumab-Awwb have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Bevacizumab-Awwb interact with any supplements?
Yes. Bevacizumab-Awwb has documented interactions with 1 supplement in our database — Polydextrose is not one of them. The Bevacizumab-Awwb interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bevacizumab-Awwb and Polydextrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.