Hydrochlorothiazide Interactions
Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Brand Names Associated with Hydrochlorothiazide
- Accuretic® (as a combination product containing Quinapril, Hydrochlorothiazide)
- Apresazide® (as a combination product containing Hydralazine, Hydrochlorothiazide)
- Benicar® HCT (as a combination product containing Olmesartan, Hydrochlorothiazide)
- Diovan® HCT (as a combination product containing Valsartan, Hydrochlorothiazide)
- Dutoprol® (as a combination product containing Metoprolol, Hydrochlorothiazide)
- Esidrix®
- Exforge® HCT (as a combination product containing Amlodipine, Hydrochlorothiazide, Valsartan)
- Hydra-Zide® (as a combination product containing Hydralazine, Hydrochlorothiazide)
- Hydrap-ES® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Hydro-Reserp® (as a combination product containing Hydrochlorothiazide, Reserpine)
- Hydrochlorothiazide
- Hydrodiuril®
- Hydropres® (as a combination product containing Hydrochlorothiazide, Reserpine)
- Hydroserp® (as a combination product containing Hydrochlorothiazide, Reserpine)
- Hydroserpine® (as a combination product containing Hydrochlorothiazide, Reserpine)
- Inderide® (as a combination product containing Hydrochlorothiazide, Propranolol)
- Inderide® LA (as a combination product containing Hydrochlorothiazide, Propranolol)
- Lopressor® HCT (as a combination product containing Metoprolol, Hydrochlorothiazide)
- Mallopress® (as a combination product containing Hydrochlorothiazide, Reserpine)
- Marpres® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Microzide®
- Monopril® HCT (as a combination product containing Fosinopril, Hydrochlorothiazide)
- Normozide® (as a combination product containing Labetalol, Hydrochlorothiazide)
- Oretic®
- Quinaretic® (as a combination product containing Quinapril, Hydrochlorothiazide)
- Ser-Ap-Es® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Serathide® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Serpazide® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Serpex® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Tekturna® HCT (as a combination product containing Aliskiren, Hydrochlorothiazide)
- Teveten® HCT (as a combination product containing Eprosartan, Hydrochlorothiazide)
- Timolide® (as a combination product containing Timolol, Hydrochlorothiazide)
- Trandate HCT® (as a combination product containing Labetalol, Hydrochlorothiazide)
- Tri-Hydroserpine® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Tribenzor® (as a combination product containing Amlodipine, Hydrochlorothiazide, Olmesartan)
- Uni Serp® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Unipres® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
- Ziac® (as a combination product containing Bisoprolol, Hydrochlorothiazide)
- Zide®
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- Contraindicated
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.