Hydrochlorothiazide

89 interactions 5 explained in plain English
Also sold as: Inzirqo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Hydrochlorothiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Hydrochlorothiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Hydrochlorothiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Hydrochlorothiazide Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Hydrochlorothiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Hydrochlorothiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Hydrochlorothiazide Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Hydrochlorothiazide Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Hydrochlorothiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Hydrochlorothiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Hydrochlorothiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Hydrochlorothiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.