Hydrochlorothiazide

89 interactions 5 explained in plain English

Also sold as: Inzirqo

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Mefenamic Acid Fenoprofen Nateglinide Glipizide Meloxicam

1 Contraindicated 55 Major 33 Moderate

All (89) Contraindicated (1) Major (55) Moderate (33)

Major

Hydrochlorothiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Linagliptin Tradjenta An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Liraglutide Injection Saxenda An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Lithium Carbonate Lithobid Lithium toxicity Details Hydrochlorothiazide Lixisenatide Injection Adlyxin® An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Methotrexate Jylamvo Increased methotrexate exposure and enhanced myelosuppression Details Hydrochlorothiazide Methotrexate Injection Abitrexate® Increased methotrexate exposure and enhanced myelosuppression Details Hydrochlorothiazide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Hydrochlorothiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details

Moderate

Hydrochlorothiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Hydrochlorothiazide Amikacin Injection Amikin® An increased risk of worsening of renal function Details Hydrochlorothiazide Amikacin Oral Inhalation Arikayce An increased risk of worsening of renal function Details Hydrochlorothiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Hydrochlorothiazide Benazepril Lotensin Reduction of blood pressure Details Hydrochlorothiazide Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details Hydrochlorothiazide Calcitriol Topical Vectical Increased serum calcium levels resulting in hypercalcemia Details Hydrochlorothiazide Capecitabine Xeloda Myelosuppression (granulocytopenia) Details Hydrochlorothiazide Captopril Capoten® Reduction of blood pressure Details Hydrochlorothiazide Cholestyramine Resin Locholest® Decreased hydrochlorothiazide concentration Details Hydrochlorothiazide Cisplatin Injection Platinol-AQ® An increased risk of worsening of renal function Details Hydrochlorothiazide Colestipol Colestid Decreased hydrochlorothiazide concentration Details Hydrochlorothiazide Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details Hydrochlorothiazide Cyclophosphamide Injection Cytoxan® Injection Increased risk of myelosuppression Details Hydrochlorothiazide Cyclosporine Injection Atopica Increased risk of hyperuricemia and gout-type complications Details Hydrochlorothiazide Cyclosporine Ophthalmic Cequa Increased risk of hyperuricemia and gout-type complications Details Hydrochlorothiazide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Hydrochlorothiazide Enalapril Epaned Reduction of blood pressure Details Hydrochlorothiazide Fludrocortisone Acetate Florinef® Hypokalemia and subsequent cardiac arrhythmias Details Hydrochlorothiazide Fluorouracil Adrucil Myelosuppression (granulocytopenia) Details Hydrochlorothiazide Fluorouracil Injection Adrucil Myelosuppression (granulocytopenia) Details Hydrochlorothiazide Fluorouracil Topical Carac Myelosuppression (granulocytopenia) Details Hydrochlorothiazide Fosinopril Monopril® Reduction of blood pressure Details Hydrochlorothiazide Gentamicin Injection Garamycin® I.V. An increased risk of worsening of renal function Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.