Taking Zyrtec With Mucinex

In our latest question and answer, our pharmacist discusses whether or not there is an interaction between Zyrtec and Mucinex.

Question

Can you take Zyrtec With Mucinex?

Asked by Jon On May 07, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 07, 2022
Last updated Apr 16, 2024

Key points

  • There is no drug interaction between Zyrtec and Mucinex. They are safe to take together.

Answer

Hello and thanks for reaching out! More than happy to answer your question.

Yes, Zyrtec (cetirizine) and Mucinex (guaifenesin) may be taken together as there is no drug interaction between the two.

In fact, both products are included in many different cough/cold formulas and have a synergistic effect when used together.

What Is Zyrtec?

Zyrtec is a second-generation antihistamine and typically provides 24-hour coverage for allergic symptoms such as a runny nose and postnasal drip.

While most second-generation antihistamines are classified as 'non-drowsy', Zyrtec is not. About 10% of people who take Zyrtec report there is sedation associated with it.

Antihistamines, such as Zyrtec, are a common component of combination cough/cold products.

What Is Mucinex?

Mucinex (guaifenesin) is classified as an expectorant and helps to loosen/thin mucus, making it easier to remove from the airways. Like antihistamines, Mucinex is a common component of many different cough/cold products.

Final Words

So again, there is no problem taking both Zyrtec and Mucinex together.

In many situations, it may be beneficial as they work well together to treat many cough/cold symptoms.

References

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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