Taking Zyrtec With Mucinex
In our latest question and answer, our pharmacist discusses whether or not there is an interaction between Zyrtec and Mucinex.

Question
Can you take Zyrtec With Mucinex?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 27, 2025
Key points
- There is no drug interaction between Zyrtec and Mucinex. They are safe to take together.
Answer
Hello and thanks for reaching out! More than happy to answer your question.
Yes, Zyrtec (cetirizine) and Mucinex (guaifenesin) may be taken together as there is no drug interaction between the two.
In fact, both products are included in many different cough/cold formulas and have a synergistic effect when used together.
What Is Zyrtec?
Zyrtec is a second-generation antihistamine and typically provides 24-hour coverage for allergic symptoms such as a runny nose and postnasal drip.
While most second-generation antihistamines are classified as 'non-drowsy', Zyrtec is not. About 10% of people who take Zyrtec report there is sedation associated with it.
Antihistamines, such as Zyrtec, are a common component of combination cough/cold products.
What Is Mucinex?
Mucinex (guaifenesin) is classified as an expectorant and helps to loosen/thin mucus, making it easier to remove from the airways. Like antihistamines, Mucinex is a common component of many different cough/cold products.
Final Words
So again, there is no problem taking both Zyrtec and Mucinex together.
In many situations, it may be beneficial as they work well together to treat many cough/cold symptoms.
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Dr. Brian Staiger, PharmD
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