What Cough Medication Is Safe While On Dialysis?
In our latest question and answer, the pharmacist discusses over-the-counter cough medications that are safe to use while undergoing dialysis.

Question
My husband is on dialysis 3 days a week. I was wondering what is the best over-the-counter cough medicine that he can take.

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 16, 2025
Key points
- Several over-the-counter cough medications are safe for those undergoing dialysis, or have kidney impairment, including dextromethorphan (Delsym) and guaifenesin (Mucinex).
Answer
Thanks for reaching out to us. Great question! It is always a good idea to look into the safety of medications if you are undergoing dialysis or have any sort of kidney impairment. It's not uncommon that a particular medication may not be safe, or dosage adjustments are needed.
In terms of cough medications, fortunately, many safe options are available over the counter for those on dialysis.
Safe Over The Counter Cough Medications - Dialysis
Dextromethorphan (brand name Delsym) is one of the most commonly used over-the-counter medications for cough and it is considered to be safe to use in those undergoing dialysis.
Based on the data available, dosage adjustments are not needed for dextromethorphan for those with kidney impairment.
Additionally, there have been no case studies linking adverse reactions in those taking dextromethorphan while on dialysis. One case report did report toxicity in one patient, but it appears the toxicity was not related to any problems with kidney function.
In addition to dextromethorphan, the expectorant guaifenesin (brand name Mucinex) is safe to use in those with kidney impairment or undergoing dialysis.
Below are some common brand names of cough medications that are safe to use are:
- Delsym (dextromethorphan)
- Robitussin (dextromethorphan)
- Robitussin DM (dextromethorphan & guaifenesin)
- Mucinex (guaifenesin)
- Mucinex DM (dextromethorphan & guaifenesin)
Final Words
Thanks again for your question! You can feel safe using dextromethorphan, guaifenesin, or both, as they are safe for the situation you described.
If you have any questions about other medications, please feel free to reach back out!
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Dr. Brian Staiger, PharmD
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