Zarbee's Cough And Mucus With Zyrtec

There are no known interactions between the two products.

2 min read Updated Jun 2026 Read by 17,555 people
Zarbee's Cough And Mucus With Zyrtec
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Brooke asked

Can I give my 3yr old daughter (23 pounds) Zarbee's Cough and Mucus along with her Zyrtec?

Sep 15, 2022
The quick answer
  • Zarbee's Cough and Mucus has no known drug interactions with Zyrtec and is considered safe to take together.
  • Using both medications together may help improve cough and allergy symptoms more than using either one alone.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Zarbee's Cough and Mucus syrup is considered safe to take with Zyrtec (cetirizine), an antihistamine, as there is no known interaction between them.

When considering drug interactions, it is important to take note of all of the active ingredients in question.

For example, Zarbee's cough syrup contains multiple active ingredients, all of which need to be considered when looking for drug interactions.

Zarbee's Cough And Mucus

There are two Zarbee's Cough and Mucus products available, a children's version and a 'baby' version.

The children's version contains the following ingredients:

  • Dark honey
  • English Ivy Leaf Extract
  • Grapefruit Seed Extract
  • Vitamin C (ascorbic acid)
  • Zinc (zinc gluconate)

The baby version contains the following:

  • Organic Agave Syrup
  • English Ivy Leaf Extract

The notable exclusion from the baby product is honey since most sources recommend against the use of honey in infants due to the risk of botulism.

Zyrtec With Zarbee's

None of the ingredients used in Zarbee's Cough and Mucus are known to interact with Zyrtec.

In fact, all of the active ingredients in Zarbee's products have few known drug interactions.

English ivy has no known drug interactions and while grapefruit juice is notorious for its potential effects on many drugs, grapefruit seed extract isn't thought to have the same precautions (although it has been reported to affect the blood thinner warfarin).

Additionally, taking Zyrtec and Zarbee's together isn't thought to increase the incidence of side effects for either.

Final Words

To answer your question specifically, there shouldn't be a problem giving your 3-year-old daughter Zyrtec and Zarbee's together. Using both may help to improve the symptoms your daughter is experiencing more than either alone.

References & sources
  1. Zarbee's Manufacturer Website — Zarbee's
  2. Zarbee's Children's Cough And Mucus Product Information — Zarbee's
  3. Therapeutic Research Center Natural Standard: English Ivy Monograph — Natural Standard (Subscription Required)
  4. Therapeutic Research Center Natural Standard: Grapefruit Monograph — Natural Standard (Subscription Required)
  5. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy — PubMed
Glossary — Terms in This Answer
Antihistamine
A medication that blocks the effects of histamine in the body to reduce allergy symptoms like itching and sneezing.
Drug interactions
Changes in how a medication works when taken together with another drug, which can reduce effectiveness or cause harmful effects.
Active ingredients
The chemical substances in a medication that produce the intended therapeutic effect.
Botulism
A serious food poisoning illness caused by a bacterial toxin that can be found in honey and is dangerous for infants.
Ascorbic acid
A form of vitamin C that helps support immune function and acts as an antioxidant.
Blood thinner
A medication that reduces the ability of blood to clot, helping to prevent dangerous blood clots.
Side effects
Unwanted or unintended physical reactions that occur when taking a medication in addition to the desired effect.
Warfarin
A commonly prescribed blood thinner medication used to prevent clots in patients at risk for stroke or other clotting conditions.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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