Interaction Details

Sorafenib is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro research suggests that calamus inhibits cytochrome P450 3A4 (CYP3A4). Theoretically, use of calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.

Calamus Overview

Calamus Calamus is a grass-like plant commonly mostly commonly found in Eastern Europe in swamps or along the banks of waterways. Calamus has traditionally been used in both Ayurdevic and Chinese medicine for a number of ailments, including digestive disorders including colic, ulcers, gastritis, flatulence, diarrhea, intestinal infections, dyspepsia, and anorexia. It is also used to induce vomiting, induce sweating, improve memory and for the treatment of inflammatory disorders. The FDA does not allow calamus in food due research showing it has carcinogenic effects, likely due to the beta-asarone content, which can vary heavily depending on the species.
See More Information Regarding Calamus

Sorafenib Overview

  • Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

See More Information Regarding Sorafenib

Calamus - More Interactions

Calamus interacts with 1071 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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