Abacavir

15 interactions 9 explained in plain English 98 cited references
Also sold as: Ziagen Ziagen®
About Abacavir

Abacavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Abacavir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although abacavir does not cure HIV, it may decrease your chance o… Read the full Abacavir drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Atidarsagene Autotemcel Azathioprine Cabotegravir Etuvetidigene Autotemcel Levoketoconazole Mercaptopurine
12 Major 3 Moderate
All (15) Major (12) Moderate (3)

Major

Abacavir Atidarsagene Autotemcel Lenmeldy Explained Interference with the manufacturing of atidarsagene autotemcel Details Abacavir Azathioprine Azasan An increased risk of hepatotoxicity Details Abacavir Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Abacavir Etuvetidigene Autotemcel Explained An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Abacavir Levoketoconazole Recorlev Explained Increased risk of serious hepatotoxicity and drug-induced liver injury Details Abacavir Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Abacavir Methadone Diskets Explained Increased methadone plasma clearance and reduced methadone exposure Details Abacavir Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Abacavir Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details Abacavir Ribavirin Copegus® Explained Fatal or nonfatal lactic acidosis Details Abacavir Tacrolimus Astagraf Explained An increased risk of nephrotoxicity Details Abacavir Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Abacavir Alosetron Explained Increased alosetron exposure Details Abacavir Riociguat Adempas Explained Increased riociguat exposure and an increased risk of riociguat-related adverse reactions Details Abacavir Tipranavir Aptivus Explained Decreased abacavir levels Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.