Abemaciclib and Adenovirus Vaccine Type 7, Live: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 10, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Abemaciclib
Adenovirus Vaccine Type 7, Live
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Abemaciclib (Verzenio) is a cancer medicine that can weaken your immune system, the body's defense against germs. The live adenovirus type 7 vaccine contains a weakened but still living virus. In a healthy person, the immune system easily controls that weakened virus. But if your defenses are lowered by chemotherapy, the vaccine virus itself could actually cause an infection instead of just teaching your body to fight it.
The good news is your care team knows how to handle this. They will look at your treatment and timing before giving any live vaccine. Please don't start or stop anything on your own, just talk with your oncologist or pharmacist first.
Direction: Abemaciclib-associated immunosuppression reduces the host response needed to contain a live attenuated vaccine, raising the risk of vaccine-derived infection. Neither agent is metabolically transformed here; this is a pharmacodynamic (immune) interaction, not a CYP-mediated one.
- Mechanism: blunted immune response permits replication of the live adenovirus type 7 vaccine.
- Severity/evidence: major, established.
- Management: generally avoid live vaccines in severely immunocompromised patients. Live vaccination may be considered once disease is in remission, immunocompetence is restored, and chemotherapy has been discontinued for at least 3 months. Coordinate timing with oncology.
What happens
An increased risk of infection by the live vaccine
Interaction Deep Dive
As a rule, live vaccines are contraindicated in patients who are severely immunocompromised2. In immunocompromised persons, the safety and efficacy of adenovirus type 7 have not been assessed3. A live vaccine may be given to individuals with leukemia, lymphoma, or other malignancies provided their disease is in remission, their immunocompetence has been restored, and at least 3 months have passed since chemotherapy was stopped1.
Why it happens (mechanism)
Decreased immune response allows live vaccine to produce infection
How to manage this interaction
Keep taking abemaciclib exactly as prescribed and do not receive the live adenovirus type 7 vaccine without clearing it with your cancer team first.
- Live vaccines are generally avoided while you are severely immunocompromised.
- Vaccination may become appropriate once your disease is in remission, your immune system has recovered, and chemotherapy has been stopped for at least 3 months.
- Your team will individualize timing based on your treatment status.
Tell any provider offering a vaccine that you are on cancer therapy, and check with your oncologist or pharmacist before any immunization.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Abemaciclib and Adenovirus Vaccine Type 7, Live together?
Abemaciclib can weaken your immune system, so a live adenovirus type 7 vaccine could cause infection; live vaccines are generally avoided until your immune system recovers and chemo has been stopped for at least 3 months. Always clear vaccines with your oncology team first. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Abemaciclib and Adenovirus Vaccine Type 7, Live interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Abemaciclib and Adenovirus Vaccine Type 7, Live interaction managed?
Keep taking abemaciclib exactly as prescribed and do not receive the live adenovirus type 7 vaccine without clearing it with your cancer team first. Live vaccines are generally avoided while you are severely immunocompromised. Vaccination may become appropriate once your disease is in remission, your immune system has recovered, and chemotherapy has been stopped for at least 3 months. Your team wi… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Abemaciclib or Adenovirus Vaccine Type 7, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Centers for Disease Control and Prevention (CDC): Vaccines & Immunizations: altered immunocompetence. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- National Center for Immunization and Respiratory Diseases (NCIRD): Vaccines & immunizations: contraindications and precautions. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- Product Information: Adenovirus type 4 and type 7 vaccine live oral enteric- coated tablets, adenovirus type 4 and type 7 vaccine live oral enteric coated tablets. Teva Pharmaceuticals USA Inc (per FDA), North Wales, PA, 2019. DailyMed
Keep reading about Abemaciclib
Keep reading about Adenovirus Vaccine Type 7, Live
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