Acebutolol

188 interactions 1 explained in plain English 508 cited references

Also sold as: Sectral®

About Acebutolol

Acebutolol is used to treat high blood pressure. Acebutolol also is used to treat an irregular heartbeat. Acebutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition a… Read the full Acebutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 16, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Olodaterol Oral Inhalation Vilanterol Verapamil Terbutaline Taletrectinib

35 Major 153 Moderate

All (188) Major (35) Moderate (153)

Moderate

Acebutolol Feprazone Reduced antihypertensive effect Details Acebutolol Floctafenine Reduced antihypertensive effect Details Acebutolol Flufenamic Acid Reduced antihypertensive effect Details Acebutolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Acebutolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Glucagon A transient increase in pulse and blood pressure Details Acebutolol Glyburide DiaBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Ibuprofen Addaprin Reduced antihypertensive effect Details Acebutolol Indomethacin Indocin Reduced antihypertensive effect Details Acebutolol Insulin Aspart, Recombinant Fiasp Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Degludec Tresiba Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Detemir Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Glargine, Recombinant Basaglar Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Glulisine Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Human Inhaled Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Human Isophane (Nph) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Human Regular Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Lispro, Recombinant Admelog Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Ketoprofen Actron® Reduced antihypertensive effect Details Acebutolol Ketorolac Acular Reduced antihypertensive effect Details Acebutolol Lidoflazine Hypotension, bradycardia, and AV conduction disturbances Details Acebutolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Liraglutide Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Lixisenatide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Lornoxicam Reduced antihypertensive effect Details Acebutolol Loxoprofen Reduced antihypertensive effect Details Acebutolol Lumiracoxib Reduced antihypertensive effect Details Acebutolol Ma Huang Reduced hypotensive effect of beta-adrenergic blockers Details Acebutolol Meclofenamate Meclodium® Reduced antihypertensive effect Details Acebutolol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Acebutolol Meloxicam Alloxate Reduced antihypertensive effect Details Acebutolol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Methacholine Impaired reversal of methacholine-caused bronchoconstriction Details Acebutolol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Acebutolol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Acebutolol Metildigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Morniflumate Reduced antihypertensive effect Details Acebutolol Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.