Acebutolol

188 interactions 1 explained in plain English 508 cited references

Also sold as: Sectral®

About Acebutolol

Acebutolol is used to treat high blood pressure. Acebutolol also is used to treat an irregular heartbeat. Acebutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition a… Read the full Acebutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 16, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Olodaterol Oral Inhalation Vilanterol Verapamil Terbutaline Taletrectinib

35 Major 153 Moderate

All (188) Major (35) Moderate (153)

Moderate

Acebutolol Acemetacin Reduced antihypertensive effect Details Acebutolol Acetyldigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Albiglutide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Amtolmetin Guacil Reduced antihypertensive effect Details Acebutolol Asenapine Saphris An increased risk of hypotension Details Acebutolol Atazanavir Reyataz An increased risk of PR interval prolongation Details Acebutolol Bromfenac Bromsite Reduced antihypertensive effect Details Acebutolol Bufexamac Reduced antihypertensive effect Details Acebutolol Bunazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Carbimazole Altered metabolism of the beta-adrenergic blocker Details Acebutolol Celecoxib Celebrex Reduced antihypertensive effect Details Acebutolol Chlorpropamide Diabinese® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Choline Salicylate Reduced antihypertensive effect Details Acebutolol Clonixin Reduced antihypertensive effect Details Acebutolol Cobicistat Tybost Increased antiarrhythmic exposure Details Acebutolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Deslanoside Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Dexibuprofen Reduced antihypertensive effect Details Acebutolol Dexketoprofen Reduced antihypertensive effect Details Acebutolol Diclofenac Aleve Arthritis Pain Reduced antihypertensive effect Details Acebutolol Diflunisal Dolobid Reduced antihypertensive effect Details Acebutolol Digitoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Dipyrone Reduced antihypertensive effect Details Acebutolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Droxicam Reduced antihypertensive effect Details Acebutolol Dulaglutide Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Etodolac Lodine Reduced antihypertensive effect Details Acebutolol Etofenamate Reduced antihypertensive effect Details Acebutolol Etoricoxib Reduced antihypertensive effect Details Acebutolol Etrasimod Velsipity May increase the risk of transient decrease in heart rate Details Acebutolol Exenatide Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Felbinac Reduced antihypertensive effect Details Acebutolol Fenoprofen Fenopron Reduced antihypertensive effect Details Acebutolol Fepradinol Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.