Aceclofenac

95 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ketorolac Ophthalmic Budesonide Oral Inhalation Melphalan
4 Contraindicated 56 Major 35 Moderate
All (95) Contraindicated (4) Major (56) Moderate (35)

Major

Aceclofenac Iloprost Aurlumyn An increased risk of bleeding Details Aceclofenac Ketoprofen Actron® Increased risk of bleeding Details Aceclofenac Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Aceclofenac Meclofenamate Meclodium® Increased risk of bleeding Details Aceclofenac Mefenamic Acid Ponstel® Increased risk of bleeding Details Aceclofenac Meloxicam Alloxate Increased risk of bleeding Details Aceclofenac Meloxicam Injection Alloxate Increased risk of bleeding Details Aceclofenac Melphalan Alkeran An increased risk of bleeding Details Aceclofenac Melphalan Injection Alkeran An increased risk of bleeding Details Aceclofenac Mesalamine Apriso Increased risk of bleeding Details Aceclofenac Mesalamine Rectal Canasa Increased risk of bleeding Details Aceclofenac Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Aceclofenac Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Aceclofenac Nabumetone Relafen Increased risk of bleeding Details Aceclofenac Naproxen Aleve Increased risk of bleeding Details Aceclofenac Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.