Aceclofenac

95 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ketorolac Ophthalmic Budesonide Oral Inhalation Melphalan

4 Contraindicated 56 Major 35 Moderate

All (95) Contraindicated (4) Major (56) Moderate (35)

Moderate

Aceclofenac Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Atenolol Tenormin Explained Reduced antihypertensive effect Details Aceclofenac Acebutolol Sectral® Reduced antihypertensive effect Details Aceclofenac Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Betaxolol Betoptic S Reduced antihypertensive effect Details Aceclofenac Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Aceclofenac Bisoprolol Zebeta® Reduced antihypertensive effect Details Aceclofenac Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Cholestyramine Resin Locholest® Decreased diclofenac bioavailability Details Aceclofenac Colestipol Colestid Decreased diclofenac bioavailability Details Aceclofenac Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Aceclofenac Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Entacapone Comtan Increased diclofenac exposure Details Aceclofenac Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Esmolol Brevibloc Reduced antihypertensive effect Details Aceclofenac Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Labetalol Normodyne® Reduced antihypertensive effect Details Aceclofenac Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Aceclofenac Levofloxacin Levaquin An increased risk of seizures Details Aceclofenac Levofloxacin Injection Levaquin An increased risk of seizures Details Aceclofenac Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Miconazole Buccal Oravig Increased exposure of diclofenac Details Aceclofenac Miconazole Topical Aloe Vesta Antifungal Increased exposure of diclofenac Details Aceclofenac Miconazole Vaginal Lagicam Increased exposure of diclofenac Details Aceclofenac Miconazole Aloe Vesta Antifungal Increased exposure of diclofenac Details Aceclofenac Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Aceclofenac Nadolol Corgard Reduced antihypertensive effect Details Aceclofenac Nebivolol Bystolic Reduced antihypertensive effect Details Aceclofenac Ofloxacin Floxin® An increased risk of seizures Details Aceclofenac Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Aceclofenac Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Aceclofenac Penbutolol Levatol® Reduced antihypertensive effect Details Aceclofenac Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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