Adalimumab and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Injection
Adalimumab
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered cycloSPORINE exposure
Interaction Deep Dive
The formation of CYP450 enzymes may be suppressed by increased concentrations of cytokines during chronic inflammation. It is possible for products that antagonize cytokine activity, such as adalimumab products, to influence the formation of CYP450 enzymes. Upon initiation or discontinuation of adalimumab in patients being treated with CYP450 substrates with a narrow therapeutic index such as cycloSPORINE, consider monitoring cycloSPORINE concentrations and adjusting the dose as needed1.
Why it happens (mechanism)
Altered formation of CYP450 enzymes due to adalimumab-mediated antagonistic effects on cytokines
Common questions
Can I take Adalimumab and Cyclosporine Injection together?
Altered cycloSPORINE exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Adalimumab and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Adalimumab or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Yusimry(TM) subcutaneous injection, adalimumab-aqvh subcutaneous injection. Coherus BioSciences, Inc (per FDA), Redwood City, CA, 2023. DailyMed
Keep reading about Cyclosporine Injection
Keep reading about Adalimumab
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