Drug Interaction Report

Albendazole and Carbamazepine: Interaction Details

A pharmacist-reviewed analysis of the Albendazole and Carbamazepine interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 10, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Carbamazepine

Carbatrol Epitol Equetro Tegretol
+

Albendazole

Albendamax Albenza Albenza® Valbazen
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 10, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 13 documented Albendazole interactions, 8 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced albendazole exposure

Interaction Deep Dive

Concomitant use of albendazole, a CYP3A4 substrate, and carBAMazepine, a CYP3A4 inducer, may reduce albendazole exposure. If coadministered, monitor the patient and consider dose adjustments if needed12. Thus, if a patient has been titrated to a stable dosage on albendazole, and then begins a course of treatment with carBAMazepine, it is reasonable to expect that a dose increase for albendazole may be necessary 3.

Why it happens (mechanism)

Induction of CYP3A4-mediated metabolism of albendazole

Common questions

Can I take Albendazole and Carbamazepine together?

Reduced albendazole exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Albendazole and Carbamazepine interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Albendazole or Carbamazepine need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: Tegretol(R)-XR oral extended-release tablets, carbamazepine oral extended-release tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
  2. Product Information: Tegretol(R) oral chewable tablets, oral tablets, oral suspension, carbamazepine oral chewable tablets, oral tablets, oral suspension. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
  3. Product Information: CARBATROL(R) oral extended-release capsules, carbamazepine oral extended-release capsules. Takeda Pharmaceuticals America Inc (per FDA), Lexington, MA, 2023. DailyMed
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Carbamazepine

Keep reading about Carbamazepine

All Carbamazepine interactions (256)
Also serious with: Lurasidone Linezolid Injection Doravirine Lenacapavir Oral
Albendazole

Keep reading about Albendazole

All Albendazole interactions (13) Albendazole drug information
Also serious with: Azathioprine Fosphenytoin Levoketoconazole Mercaptopurine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Carbamazepine + 1,4-butanediol Activated Charcoal Asarabacca Beer Gamma-hydroxybutyrate (ghb) Grapefruit Kava L-tryptophan + 276 more
Albendazole + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Sassafras Slippery Elm + 10 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.