Alfentanil

100 interactions 7 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Alfentanil Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Alfentanil Dolasetron Anzemet Increased risk of serotonin syndrome Details Alfentanil Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Alfentanil Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Alfentanil Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Alfentanil Entrectinib Rozlytrek Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Erdafitinib Balversa Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Esketamine Nasal Spray Spravato Increased ALfentanil exposure and an increased risk of respiratory or CNS depression and hypotension Details Alfentanil Esomeprazole Nexium Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Esomeprazole Injection Nexium Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Estradiol Delestrogen Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Estradiol Topical Divigel Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Estradiol Transdermal Patch Alora® Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Everolimus Afinitor Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Alfentanil Fostamatinib Tavalisse Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Glycopyrronium Topical Cuvposa® An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Alfentanil Granisetron Injection Granisol Increased risk of serotonin syndrome Details Alfentanil Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Alfentanil Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Alfentanil Hydroxychloroquine Plaquenil An increased risk of seizures Details Alfentanil Ibrexafungerp Brexafemme Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Ipratropium Oral Inhalation Atrovent® HFA An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Istradefylline Nourianz Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Ketoconazole Topical Extina® Foam Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Lacosamide Injection Motpoly An increased risk of CNS depression Details Alfentanil Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Alfentanil Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Alfentanil Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Alfentanil Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Alfentanil Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Alfentanil Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Alfentanil Levonorgestrel After banger Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Levonorgestrel Intrauterine System Kyleena Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Linagliptin Tradjenta Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Linezolid Injection Zyvox An increased risk of hypertension, and an increased risk of serotonin syndrome or opioid toxicity Details Alfentanil Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Alfentanil Lumateperone Caplyta Increased ALfentanil exposure and an increased risk of respiratory depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.