Alogliptin

129 interactions 209 cited references

Also sold as: Nesina Nesina®

About Alogliptin

Alogliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Alogliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by incre… Read the full Alogliptin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Insulin Degludec (Rdna Origin) Injection Abiraterone Abiraterone Acetate Abiraterone Acetate, Micronized Ofloxacin Otic

1 Contraindicated 81 Major 47 Moderate

All (129) Contraindicated (1) Major (81) Moderate (47)

Major

Alogliptin Lomefloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Alogliptin Mavorixafor Xolremdi Increased mavorixafor exposure and an increased risk of mavorixafor-related adverse effects Details Alogliptin Metolazone An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Morphine Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Alogliptin Morphine Sulfate Liposome Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Alogliptin Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Norfloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Octreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Pasireotide Diaspartate An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Polythiazide An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Posaconazole Noxafil Increased posaconazole exposure Details Alogliptin Pramlintide Symlin An increased risk of hypoglycemia Details Alogliptin Ranolazine Aspruzyo Increased ranolazine exposure and an increased risk of ranolazine-related adverse effects Details Alogliptin Repotrectinib Augtyro Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Alogliptin Somatrogon-Ghla Reduced insulin sensitivity Details Alogliptin Sparfloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Thioctic Acid Increased risk of hypoglycemia Details Alogliptin Tramadol ConZip Increased traMADol exposure and reduced exposure of the active metabolite Details Alogliptin Triamterene Dyrenium An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Trovafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Venetoclax Venclexta Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Alogliptin Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Alogliptin Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Alogliptin Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Alogliptin Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Alogliptin Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Alogliptin Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Alogliptin Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Alogliptin Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.