Alteplase, Recombinant

34 interactions 2 explained in plain English

Also sold as: Activase

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Heparin Apixaban Captopril Perindopril Dipyridamole

1 Contraindicated 30 Major 3 Moderate

All (34) Contraindicated (1) Major (30) Moderate (3)

Contraindicated

Alteplase, Recombinant Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Alteplase, Recombinant Lisinopril Prinivil Explained An increased risk of orolingual angioedema Details Alteplase, Recombinant Apixaban Eliquis Explained An increased risk of bleeding Details Alteplase, Recombinant Aspirin Acuprin® An increased risk of bleeding Details Alteplase, Recombinant Aspirin Rectal Aspirin An increased risk of bleeding Details Alteplase, Recombinant Betrixaban Bevyxxa® Increased risk of bleeding Details Alteplase, Recombinant Benazepril Lotensin An increased risk of orolingual angioedema Details Alteplase, Recombinant Caplacizumab-Yhdp Injection Cablivi Increased risk of bleeding Details Alteplase, Recombinant Captopril Capoten® An increased risk of orolingual angioedema Details Alteplase, Recombinant Clopidogrel Plavix An increased risk of bleeding Details Alteplase, Recombinant Dabigatran Pradaxa® An increased risk of bleeding Details Alteplase, Recombinant Dabigatran Etexilate An increased risk of bleeding Details Alteplase, Recombinant Dalteparin Injection Fragmin An increased risk of bleeding Details Alteplase, Recombinant Dipyridamole Permole® An increased risk of bleeding Details Alteplase, Recombinant Edoxaban Savaysa An increased risk of bleeding Details Alteplase, Recombinant Enalapril Epaned An increased risk of orolingual angioedema Details Alteplase, Recombinant Enoxaparin Lovenox Increased risk of bleeding Details Alteplase, Recombinant Enoxaparin Injection Lovenox Increased risk of bleeding Details Alteplase, Recombinant Fondaparinux Arixtra An increased risk of bleeding Details Alteplase, Recombinant Fondaparinux Injection Arixtra An increased risk of bleeding Details Alteplase, Recombinant Fosinopril Monopril® An increased risk of orolingual angioedema Details Alteplase, Recombinant Heparin An increased risk of bleeding Details Alteplase, Recombinant Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Alteplase, Recombinant Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities or intracerebral hemorrhage Details Alteplase, Recombinant Moexipril Univasc® An increased risk of orolingual angioedema Details Alteplase, Recombinant Nitroglycerin Gonitro Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Alteplase, Recombinant Nitroglycerin Spray Nitrolingual Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Alteplase, Recombinant Nitroglycerin Sublingual Nitrostat Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Alteplase, Recombinant Nitroglycerin Topical Nitro-Bid Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Alteplase, Recombinant Nitroglycerin Transdermal Patch Minitran® Patch Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Alteplase, Recombinant Perindopril Aceon An increased risk of orolingual angioedema Details

Moderate

Alteplase, Recombinant Capsaicin Arthricare for Women Moisturizing Increased risk of bleeding Details Alteplase, Recombinant Capsaicin Topical Aspercreme Warming® Increased risk of bleeding Details Alteplase, Recombinant Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.