Amikacin Oral Inhalation

75 interactions 361 cited references
Also sold as: Arikayce Arikayce®
About Amikacin Oral Inhalation

Amikacin oral inhalation is used in combination with other antibiotics to treat Mycobacterium avium complex lung disease (MAC; a bacterial infection that may cause serious symptoms) that has not responded well to other antibiotics. Amikacin is in a class of medications called aminoglycoside antibiotics. It works by kil… Read the full Amikacin Oral Inhalation drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ataluren Vecuronium Colistimethate Sodium Cisatracurium Cidofovir Cefepime
1 Contraindicated 35 Major 13 Moderate 26 Minor
All (75) Contraindicated (1) Major (35) Moderate (13) Minor (26)

Contraindicated

Amikacin Oral Inhalation Ataluren Decreased ataluren activity and increased risk of aminoglycoside-associated nephrotoxicity Details

Major

Amikacin Oral Inhalation Alcuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Amikacin Oral Inhalation Atracurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Bumetanide Bumex An increased risk of ototoxicity Details Amikacin Oral Inhalation Cefepime An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Amikacin Oral Inhalation Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Amikacin Oral Inhalation Cidofovir Nephrotoxicity Details Amikacin Oral Inhalation Cisatracurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Colistimethate Sodium Respiratory depression Details Amikacin Oral Inhalation Decamethonium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Doxacurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Amikacin Oral Inhalation Ethacrynic Acid Edecrin Increased amikacin plasma and tissue concentrations and additive ototoxicity Details Amikacin Oral Inhalation Fazadinium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Foscarnet Foscavir Nephrotoxicity Details Amikacin Oral Inhalation Furosemide Disal Increased amikacin exposure and an increased risk of ototoxicity and/or nephrotoxicity Details Amikacin Oral Inhalation Gallamine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Hexafluorenium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Letibotulinumtoxina-Wlbg Letybo Increased neuromuscular weakness Details Amikacin Oral Inhalation Lysine Increased risk of nephrotoxicity Details Amikacin Oral Inhalation Mannitol Alteration of serum and tissue amikacin concentrations Details Amikacin Oral Inhalation Metocurine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Mivacurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Pancuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Pipecuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Rapacuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Rocuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Succinylcholine Anectine Succinylcholine toxicity (respiratory depression) Details Amikacin Oral Inhalation Tacrolimus Astagraf An increased risk of nephrotoxicity Details Amikacin Oral Inhalation Teicoplanin Increased risk of nephrotoxicity and/or ototoxicity Details Amikacin Oral Inhalation Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Amikacin Oral Inhalation Tubocurarine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Amikacin Oral Inhalation Urea Atrac-Tain Alteration of serum and tissue amikacin concentrations Details Amikacin Oral Inhalation Vancomycin Firvanq An increased risk of ototoxicity and/or an increased risk of nephrotoxicity Details Amikacin Oral Inhalation Vecuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details

Moderate

Amikacin Oral Inhalation Capreomycin Amikacin toxicity (ototoxicity, nephrotoxicity) Details Amikacin Oral Inhalation Carboplatin Kyxata Ototoxicity Details Amikacin Oral Inhalation Cyclosporine Atopica Renal dysfunction or nephrotoxicity Details Amikacin Oral Inhalation Hydrochlorothiazide Inzirqo An increased risk of worsening of renal function Details

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