Amiloride

49 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amiloride Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Amiloride Lisinopril Prinivil Explained Increased risk of hyperkalemia Details Amiloride Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Amiloride Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Amiloride Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Amiloride Aspirin Acuprin® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Aspirin Rectal Aspirin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Benazepril Lotensin Increased risk of hyperkalemia Details Amiloride Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Captopril Capoten® Increased risk of hyperkalemia Details Amiloride Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Amiloride Cyclosporine Injection Atopica An increased risk of hyperkalemia Details Amiloride Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia Details Amiloride Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Dofetilide Tikosyn Increased dofetilide exposure Details Amiloride Enalapril Epaned Increased risk of hyperkalemia Details Amiloride Etodolac Lodine Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Fenoprofen Fenopron Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Amiloride Flurbiprofen Ansaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Fosinopril Monopril® Increased risk of hyperkalemia Details Amiloride Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Amiloride Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Amiloride Ibuprofen Addaprin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Ketoprofen Actron® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Ketorolac Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Ketorolac Injection Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Ketorolac Ophthalmic Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Meclofenamate Meclodium® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Mefenamic Acid Ponstel® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Meloxicam Alloxate Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Meloxicam Injection Alloxate Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Amiloride Moexipril Univasc® Increased risk of hyperkalemia Details Amiloride Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Amiloride Nabumetone Relafen Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.