Aminoglutethimide and Medroxyprogesterone Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Medroxyprogesterone Injection
Aminoglutethimide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased medroxyPROGESTERone efficacy
Interaction Deep Dive
Concurrent administration of medroxyPROGESTERone and aminoglutethimide may result in significantly reduced bioavailability of medroxyPROGESTERone12, and the therapeutic effect may be reduced. MedroxyPROGESTERone metabolism is probably enhanced due to aminoglutethimide enzyme induction.
Why it happens (mechanism)
Increased medroxyPROGESTERone metabolism
Common questions
Can I take Aminoglutethimide and Medroxyprogesterone Injection together?
Decreased medroxyPROGESTERone efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aminoglutethimide and Medroxyprogesterone Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Aminoglutethimide or Medroxyprogesterone Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: Provera(R), medroxyprogesterone. The Upjohn Company, Kalamazoo, MI, 1992. DailyMed
- Van Deijk WA, Blijham GH, Mellink WA, et al: Influence of aminoglutethimide on plasma levels of medroxyprogesterone acetate: its correlation with serum cortisol. Cancer Treat Rep 1985; 69:85-90.
Keep reading about Medroxyprogesterone Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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