Medroxyprogesterone Injection

103 interactions 317 cited references
Also sold as: Depo-Provera Depo-Provera® depo-subQ provera depo-subQ provera 104® Provera
About Medroxyprogesterone Injection

Medroxyprogesterone intramuscular (into a muscle) injection and medroxyprogesterone subcutaneous (under the skin) injection are used to prevent pregnancy. Medroxyprogesterone subcutaneous injection is also used to treat endometriosis (a condition in which the type of tissue that lines the uterus (womb) grows in other a… Read the full Medroxyprogesterone Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Medroxyprogesterone Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Injection Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Medroxyprogesterone Injection Apalutamide Erleada Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Medroxyprogesterone Injection Armodafinil Nuvigil Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Injection Belzutifan Welireg An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Medroxyprogesterone Injection Bexarotene Targretin Decreased contraceptive effectiveness Details Medroxyprogesterone Injection Bosentan Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Carbamazepine Carbatrol Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Cenobamate Xcopri Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Medroxyprogesterone Injection Clobazam Onfi Decreased contraceptive effectiveness Details Medroxyprogesterone Injection Clomipramine Anafranil Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Medroxyprogesterone Injection Dabrafenib Tafinlar Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Injection Darunavir Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and an increased darunavir exposure Details Medroxyprogesterone Injection Dexamethasone Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Medroxyprogesterone Injection Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Medroxyprogesterone Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Medroxyprogesterone Injection Efavirenz Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Elafibranor Iqirvo Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and/or an increased risk of breakthrough ble... Details Medroxyprogesterone Injection Elagolix Orilissa Increased estrogen exposure, reduced progestin efficacy, and reduced elagolix efficacy Details Medroxyprogesterone Injection Elvitegravir Altered contraceptive effectiveness and risk of side effects Details Medroxyprogesterone Injection Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Medroxyprogesterone Injection Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Injection Enzalutamide Xtandi Reduced medroxyPROGESTERone exposure Details Medroxyprogesterone Injection Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Medroxyprogesterone Injection Eslicarbazepine Acetate Aptiom Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Medroxyprogesterone Injection Etravirine Intelence Reduced medroxyPROGESTERone exposure Details

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