Drug Interaction Report

Amiodarone and Degarelix Injection: Interaction Details

A pharmacist-reviewed analysis of the Amiodarone and Degarelix Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Amiodarone

Nexterone Pacerone
+

Degarelix Injection

Firmagon Firmagon®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 141 documented Amiodarone interactions, 111 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of QT prolongation

Interaction Deep Dive

Coadministration of amiodarone and gonadotropin-releasing hormone (GnRH) agonists/antagonists is generally not recommended4. Androgen deprivation caused by GnRH agonists or antagonists may prolong the QT interval and cause additive effects when administered with QT-interval prolonging drugs 123. If concurrent therapy is necessary, monitor patients closely for signs and symptoms of cardiac toxicity, including changes in the ECG.

Why it happens (mechanism)

Additive effects on QT interval

Common questions

Can I take Amiodarone and Degarelix Injection together?

Increased risk of QT prolongation Always confirm with your pharmacist or prescriber before making any change.

How serious is the Amiodarone and Degarelix Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Amiodarone or Degarelix Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: TRELSTAR(R) intramuscular injection suspension, triptorelin pamoate intramuscular injection suspension. Actavis Pharma, Inc. (per FDA), Parsippany, NJ, 2014.
  2. Product Information: VANTAS(R) subcutaneous implant, histrelin acetate subcutaneous implant. Endo Pharmaceuticals Solutions Inc. (per DailyMed), Malvern, PA, 2014. DailyMed
  3. Product Information: LUPRON DEPOT intramuscular injection depot suspension, leuprolide acetate intramuscular injection depot suspension. AbbVie Inc. (per FDA), North Chicago, IL, 2014.
  4. Product Information: NEXTERONE(TM) intravenous injection, amiodarone HCl intravenous injection. Baxter Healthcare Corporation (per FDA), Deerfield, IL, 2015. DailyMed
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Amiodarone

Keep reading about Amiodarone

All Amiodarone interactions (141)
Also serious with: Deuruxolitinib Colchicine Ketoconazole Topical Galantamine
Degarelix Injection

Keep reading about Degarelix Injection

All Degarelix Injection interactions (226) Degarelix Injection drug information
Also serious with: Levoketoconazole Measles Virus Vaccine, Live Mesoridazine Mumps Virus Vaccine, Live
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Amiodarone + Activated Charcoal American Hellebore Arsenic Beer Cesium Ephedra Grapefruit Siberian Cocklebur + 202 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.