Amlodipine

195 interactions 821 cited references
Also sold as: Amvaz® Katerzia Katerzia® Norliqva Norvasc Norvasc® Sdamlo
About Amlodipine

Amlodipine is a calcium channel blocker used to treat high blood pressure, chest pain, and narrowing of heart blood vessels. Read the full Amlodipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amlodipine Abametapir Increased exposure of CYP3A4 substrate Details Amlodipine Relugolix Orgovyx Reduced amLODIPine exposure Details Amlodipine Simvastatin Flolipid Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Amlodipine Adagrasib Krazati Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Amlodipine Amprenavir Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Amlodipine Aprepitant Aponvie Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Armodafinil Nuvigil Reduced amLODIPine exposure Details Amlodipine Artemether Increased artemether/lumefantrine exposure, an increased risk of QT prolongation, reduced CYP3A4 substrate exposure and reduced ef... Details Amlodipine Atazanavir Reyataz Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Avacopan Tavneos Increased CYP3A4 substrate exposure Details Amlodipine Belzutifan Welireg Reduced amLODIPine exposure Details Amlodipine Berotralstat Orladeyo Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Bexarotene Targretin Reduced amLODIPine exposure Details Amlodipine Boceprevir Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Bosentan Reduced amLODIPine exposure Details Amlodipine Brigatinib Alunbrig Reduced amLODIPine exposure Details Amlodipine Brivaracetam Briviact Reduced amLODIPine exposure Details Amlodipine Carbamazepine Carbatrol Reduced dihydropyridine calcium channel blockers and reduced efficacy of dihydropyridine calcium channel blockers Details Amlodipine Cenobamate Xcopri Reduced amLODIPine exposure Details Amlodipine Ceritinib Zykadia Increased CYP3A substrate exposure Details Amlodipine Ciprofloxacin Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Clarithromycin Biaxin Increased risk of hypotension, acute kidney injury, bradyarrhythmias, lactic acidosis and peripheral edema Details Amlodipine Clobazam Onfi Reduced amLODIPine exposure Details Amlodipine Clofazimine Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Amlodipine Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Amlodipine Cobicistat Tybost Increased amLODIPine exposure, an increased risk of hypotension and edema and an increased cobicistat exposure Details Amlodipine Conivaptan Vaprisol Increased CYP3A substrate exposure Details Amlodipine Crizotinib Xalkori Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Cyclosporine Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Amlodipine Dabrafenib Tafinlar Reduced amLODIPine exposure Details Amlodipine Dantrolene Dantrium Severe hyperkalemia with cardiovascular collapse Details Amlodipine Darolutamide Nubeqa Reduced amLODIPine exposure Details Amlodipine Darunavir Increased amLODIPine exposure, an increased darunavir exposure and an increased risk of amLODIPine/darunavir-related adverse effec... Details Amlodipine Dexamethasone Reduced amLODIPine exposure Details Amlodipine Dicloxacillin Reduced amLODIPine exposure Details Amlodipine Digoxin Cardoxin® An increased risk of bradycardia and an increased risk of complete heart block Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.